Evidence map›Paper›PMID 37417873›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2023

Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.

Tomoko Ichiki, Valentina Cannone, Christopher G Scott, Seethalakshmi R Iyer, S Jeson Sangaralingham, Kent R Bailey, Jens P Goetze, Yoshihisa Tsuji, Richard J Rodeheffer, John C Burnett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Tomoko IchikiCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Valentina CannoneCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-5168-8381
Christopher G ScottBiomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-1340-0647
Seethalakshmi R IyerCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
S Jeson SangaralinghamCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Kent R BaileyBiomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States.
Jens P GoetzeDepartment of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Yoshihisa TsujiDepartment of Community and General Medicine, School of Medicine, Sapporo Medical University, Sapporo, Japan.
Richard J RodehefferCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
John C BurnettCardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-3414-1659
Mayo Clinic · USSapporo Medical University · JPUniversity of Copenhagen · DKUniversity of Parma · IT

Funding

PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTIONR01HL055502 · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · 1997 to 2004
$2.7M
NHLBI NIH HHS R01 HL055502NHLBI NIH HHS R01 HL136340NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG052425NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are produced in the heart and secreted into the circulation. As hormones, both peptides activate the guanylyl cyclase receptor A (GC-A), playing a role in blood pressure (BP) regulation. A significant role for ANP and BNP includes favorable actions in metabolic homeostasis. Sex-based high prevalence of risk factors for cardiovascular disease in males compared with females is well established, but sex-based differences on cardiometabolic protection have not been investigated in relation to ANP (

Indexed as

Atrial Natriuretic FactorCardiovascular DiseasesFemaleGenotypeHumansMaleNatriuretic Peptide, BrainPhenotypeAtrial Natriuretic FactorNatriuretic Peptide, Brainatrial natriuretic peptideB-type natriuretic peptidesgene variantsmetabolic syndromesex

Identifiers

PMID37417873
PMCPMC10538992
OpenAlexW4383483558

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.