ReviewBiological psychology2023
Signal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence.
Review in Biological psychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Transauricular Vagus Nerve Stimulation in Acute Ischaemic Stroke Requiring Mechanical Thrombectomy: Sham-Controlled, Randomised Device Trial.Translational stroke research · 2025Trial
- A dense-sampling investigation of interoceptive variation across the menstrual cycle: the Cyclic Hormones and Interoception with Repeated Profiling (CHIRP) Study.Brain, behavior, & immunity - health · 2026Article
- The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026Review
- Putting Emotional Memories in Context: The Constructionist Model of Emotional Memory.Perspectives on psychological science : a journal of the Association for Psychological Science · 2026Review
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- The Role of Antioxidants in the Connection Between Microbiota, Neuroinflammation and Epilepsy.Biomedicines · 2026Review
- No significant modulation of pressure pain sensitivity and cardioception after transauricular vagal nerve stimulation.Pain reports · 2026Article
- Review
- Cardiac-vagal rhythm echoes on the heartbeat's mechanosensory imprint in the brain.Communications biology · 2025Article
- Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI.Nature neuroscience · 2025Article
- Vagal Oxytocin Receptors as Molecular Targets in Gut-Brain Signaling: Implications for Appetite, Satiety, Obesity, and Esophageal Motility-A Narrative Review.International journal of molecular sciences · 2025Review
- Dysregulated neural coding in the vagus nerve during long sepsis.Brain, behavior, & immunity - health · 2025Article
- Gut-brain communication: Functional anatomy of vagal afferents.Current opinion in neurobiology · 2025Review
- The Importance of Including Psychophysiological Methods in Psychotherapy.Applied psychophysiology and biofeedback · 2025Review
- The hidden route: an exploratory study on autonomic influences in early phases of information processing.BMC psychology · 2025Article
- Exploring the impact of maternal early life adversity on interoceptive sensibility in pregnancy: implications for prenatal depression.Archives of women's mental health · 2025Article
- Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain using 7 Tesla fMRI.bioRxiv : the preprint server for biology · 2025Article
- Integrating brainstem and cortical functional architectures.Nature neuroscience · 2024Article
- Heart Rate Variability Biofeedback Intervention Programme to Improve Attention in Primary Schools.Applied psychophysiology and biofeedback · 2024Article
- Interoception in pregnancy: Implications for peripartum depression.Neuroscience and biobehavioral reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Each organism must regulate its internal state in a metabolically efficient way as it interacts in space and time with an ever-changing and only partly predictable world. Success in this endeavor is largely determined by the ongoing communication between brain and body, and the vagus nerve is a crucial structure in that dialogue. In this review, we introduce the novel hypothesis that the afferent vagus nerve is engaged in signal processing rather than just signal relay. New genetic and structural evidence of vagal afferent fiber anatomy motivates two hypotheses: (1) that sensory signals informing on the physiological state of the body compute both spatial and temporal viscerosensory features as they ascend the vagus nerve, following patterns found in other sensory architectures, such as the visual and olfactory systems; and (2) that ascending and descending signals modulate one another, calling into question the strict segregation of sensory and motor signals, respectively. Finally, we discuss several implications of our two hypotheses for understanding the role of viscerosensory signal processing in predictive energy regulation (i.e., allostasis) as well as the role of metabolic signals in memory and in disorders of prediction (e.g., mood disorders).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.