ArticleNature communications2023
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture.Biological psychiatry global open science · 2026Article
- Amphetamine in adolescence induces a sex-specific mesolimbic dopamine phenotype in the adult prefrontal cortex.Communications biology · 2025Article
- Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks.Molecular psychiatry · 2025Review
- Divergent outcomes of delta 9 - tetrahydrocannabinol (THC) in adolescence on mesocortical dopamine and cognitive development in male and female mice.Psychopharmacology · 2025Article
- Article
- Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats.Neuropharmacology · 2025Article
- Molecular heterogeneity and development of the ventral tegmental area.Current opinion in behavioral sciences · 2025Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
- Timing of Methamphetamine Exposure during Adolescence Differentially Influences Parvalbumin and Perineuronal Net Immunoreactivity in the Medial Prefrontal Cortex of Female, but Not Male, Rats.Developmental neuroscience · 2025Article
- Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state.Nature communications · 2024Article
- Local and long-range input balance: A framework for investigating frontal cognitive circuit maturation in health and disease.Science advances · 2024Review
- Article
- Reorganization of dopamine circuitry in the anterior corpus callosum between early adolescence and adulthood in the mouse.The European journal of neuroscience · 2024Article
- Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice.Journal of visualized experiments : JoVE · 2024Article
- The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice.Biological psychiatry · 2024Article
- We're not in Kansas anymore: ectopic dopaminergic terminals as an explanation for the positive symptoms in psychiatric pathology.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 3 countries.
Funding
Abstract
Initiating drug use during adolescence increases the risk of developing addiction or other psychopathologies later in life, with long-term outcomes varying according to sex and exact timing of use. The cellular and molecular underpinnings explaining this differential sensitivity to detrimental drug effects remain unexplained. The Netrin-1/DCC guidance cue system segregates cortical and limbic dopamine pathways in adolescence. Here we show that amphetamine, by dysregulating Netrin-1/DCC signaling, triggers ectopic growth of mesolimbic dopamine axons to the prefrontal cortex, only in early-adolescent male mice, underlying a male-specific vulnerability to enduring cognitive deficits. In adolescent females, compensatory changes in Netrin-1 protect against the deleterious consequences of amphetamine on dopamine connectivity and cognitive outcomes. Netrin-1/DCC signaling functions as a molecular switch which can be differentially regulated by the same drug experience as function of an individual's sex and adolescent age, and lead to divergent long-term outcomes associated with vulnerable or resilient phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.