Evidence map›Paper›PMID 37423967›Full record

ArticlePurinergic signalling2024

Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors.

Anna Vlachodimou, Jara Bouma, Michel De Cleyn, Didier Berthelot, Stefan Pype, Jean-Paul Bosmans, Herman van Vlijmen, Berthold Wroblowski, Laura H Heitman, Adriaan P IJzerman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Purinergic signalling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna VlachodimouDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.ORCID 0000-0002-6602-8044
Jara BoumaDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.ORCID 0000-0002-6572-6158
Michel De CleynJanssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
Didier BerthelotJanssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.ORCID 0000-0001-5151-5010
Stefan PypeJanssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.ORCID 0000-0002-1544-6967
Jean-Paul BosmansJanssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.
Herman van VlijmenDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.ORCID 0000-0002-1915-3141
Berthold WroblowskiJanssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium.ORCID 0000-0002-9980-1646
Laura H HeitmanDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.ORCID 0000-0002-1381-8464
Adriaan P IJzermanDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands. ijzerman@lacdr.leidenuniv.nl.ORCID 0000-0002-1182-2259

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evaluation of kinetic parameters of drug-target binding, k

Indexed as

Equilibrative Nucleoside Transporter 1ThioinosineBiological TransportHumansEquilibrative Nucleoside Transporter 1ThioinosineAdenosine(Human) nucleoside transport protein (hENT1Radioligand binding experimentsSLC29A1)Target binding kineticsTransport inhibitors

Identifiers

PMID37423967
PMCPMC10997566

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.