Evidence map›Paper›PMID 37425713›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Differential DNA Methylation in the Brain as Potential Mediator of the Association between Traffic-related PM

Zhenjiang Li, Donghai Liang, Stefanie Ebelt, Marla Gearing, Michael S Kobor, Chaini Konwar, Julie L Maclsaac, Kristy Dever, Aliza Wingo, Allan Levey and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Zhenjiang LiGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA.
Donghai LiangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA.
Stefanie EbeltGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA.
Marla GearingDepartment of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Rd, Atlanta, GA 30322, USA.
Michael S KoborDepartment of Medical Genetics, University of British Columbia, 4500 Oak St, Vancouver, BC V6H 3N1, Canada.
Chaini KonwarDepartment of Medical Genetics, University of British Columbia, 4500 Oak St, Vancouver, BC V6H 3N1, Canada.
Julie L MaclsaacDepartment of Medical Genetics, University of British Columbia, 4500 Oak St, Vancouver, BC V6H 3N1, Canada.
Kristy DeverDepartment of Medical Genetics, University of British Columbia, 4500 Oak St, Vancouver, BC V6H 3N1, Canada.
Aliza WingoDivision of Mental Health, Atlanta VA Medical Center, 1670 Clairmont Rd, Decatur, GA 30033, USA.
Allan LeveyDepartment of Neurology, Emory University School of Medicine, 12 Executive Park Dr NE, Atlanta, GA 30322, USA.
James J LahDepartment of Neurology, Emory University School of Medicine, 12 Executive Park Dr NE, Atlanta, GA 30322, USA.
Thomas WingoDepartment of Neurology, Emory University School of Medicine, 12 Executive Park Dr NE, Atlanta, GA 30322, USA.
Anke HuelsGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA.

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WINGO, THOMAS SPURGEON · 2005 to 2019
$25.7M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Air pollution and early signs of dementiaR01AG079170 · NIA · EMORY UNIVERSITY · PI Anke Huels, Thomas Spurgeon Wingo · 2022 to 2026
$3.6M
Traffic Exposure, Maternal Metabolome and Birth Outcomes Study (TEMMBO Study)R21ES032117 · NIEHS · EMORY UNIVERSITY · PI LIANG, DONGHAI · 2021 to 2022
$420k
NIA NIH HHS P50 AG025688NIA NIH HHS R01 AG079170NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R21 ES032117
6 · The paper itself

Abstract

introductionGrowing evidence indicates fine particulate matter (PM

methodsWe assessed genome-wide DNAm (Illumina EPIC BeadChips) in prefrontal cortex tissue and three AD-related neuropathological markers (Braak stage, CERAD, ABC score) for 159 donors, and estimated donors' residential traffic-related PM

resultsPM DISCUSSION: Our findings suggest differential DNAm related to neuroinflammation mediates the association between traffic-related PM

Indexed as

Alzheimer’s diseaseDNA methylationneuropathologyTraffic-related fine particulate matter

Identifiers

PMID37425713
PMCPMC10327281

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.