Evidence map›Paper›PMID 37426193›Full record

ArticleFrontiers in nutrition2023

Characterizations of microRNAs involved in the molecular mechanisms underlying the therapeutic effects of noni (

Yue Liu, Xianjun Liu, Mengyuan Wang, Changwu Chen, Xiaohong Li, Zhiyong Liang, Yaming Shan, Yuhe Yin, Fengjie Sun, Zhandong Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yue LiuCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Xianjun LiuCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Mengyuan WangCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Changwu ChenCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Xiaohong LiCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Zhiyong LiangCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Yaming ShanNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, China.
Yuhe YinSchool of Chemistry and Life Science, Changchun University of Technology, Changchun, China.
Fengjie SunSchool of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA, United States.
Zhandong LiCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Hao LiCollege of Biological and Food Engineering, Jilin Engineering Normal University, Changchun, China.
Jilin Engineering Normal University · CNChangchun University of TechnologyGeorgia Gwinnett College · USJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hyperuricemia is generally defined as the high level of serum uric acid and is well known as an important risk factor for the development of various medical disorders. However, the medicinal treatment of hyperuricemia is frequently associated with multiple side-effects. Methods: The therapeutic effect of noni ( Results: The levels of serum uric acid (UA) and xanthine oxidase (XOD) in mice treated with noni fruit juice were significantly decreased, suggesting that the noni fruit juice could alleviate hyperuricemia by inhibiting the XOD activity and reducing the level of serum UA. The contents of both serum creatinine and blood urine nitrogen of the noni fruit juice group were significantly lower than those of the model group, suggesting that noni fruit juice promoted the excretion of UA without causing deleterious effect on the renal functions in mice. The differentially expressed microRNAs involved in the pathogenesis of hyperuricemia in mice were identified by RNA sequencing with their target genes further annotated based on both Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases to explore the metabolic pathways and molecular mechanisms underlying the therapeutic effect on hyperuricemia by noni fruit juice. Conclusion: Our study provided strong experimental evidence to support the further investigations of the potential application of noni fruit juice in the treatment of hyperuricemia.

Indexed as

blood urine nitrogencreatininehyperuricemiamicemicroRNAMorinda citrifolia fruit juiceuric acidxanthine oxidase

Identifiers

PMID37426193
PMCPMC10324520
OpenAlexW4381936529

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.