Evidence map›Paper›PMID 37429534›Full record

ArticleArchives of biochemistry and biophysics2023

Effects of ROS pathway inhibitors and NADH and FADH

Shima Sadri, Namrata Tomar, Chun Yang, Said H Audi, Allen W Cowley, Ranjan K Dash

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Sex dimorphism and substrate dependency of liver mitochondrial bioenergetics and HAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Inhibitors of Type II NADH Dehydrogenase Enzyme: A Review.Current protein & peptide science · 2025
    Review
  13. Article
  14. Complex II ambiguities-FADHThe Journal of biological chemistry · 2024
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shima SadriDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Namrata TomarDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Chun YangDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Said H AudiDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Department of Biomedical Engineering, Marquette University, Milwaukee, WI, 53223, USA.
Allen W CowleyDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Ranjan K DashDepartment of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Department of Biomedical Engineering, Marquette University, Milwaukee, WI, 53223, USA. Electronic address: rdash@mcw.edu.
Medical College of Wisconsin · USMarquette University · US

Funding

High Salt Remodels Renal Cortical and Proximal Tubular Metabolism: Metabolic Fuels, Oxidative Stress, and HypertensionR01HL151587 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Allen W Cowley, Ranjan K Dash · 2021 to 2026
$3.7M
NHLBI NIH HHS R01 HL151587
6 · The paper itself

Abstract

Mitochondria are major sources of reactive oxygen species (ROS), which play important roles in both physiological and pathological processes. However, the specific contributions of different ROS production and scavenging components in the mitochondria of metabolically active tissues such as heart and kidney cortex and outer medulla (OM) are not well understood. Therefore, the goal of this study was to determine contributions of different ROS production and scavenging components and provide detailed comparisons of mitochondrial respiration, bioenergetics, ROS emission between the heart and kidney cortex and OM using tissues obtained from the same Sprague-Dawley rat under identical conditions and perturbations. Specifically, data were obtained using both NADH-linked substrate pyruvate + malate and FADH

Indexed as

MitochondriaNADAnimalsEnergy MetabolismKidney CortexRatsRats, Sprague-DawleyReactive Oxygen SpeciesNADReactive Oxygen SpeciesForward and reverse electron transferMitochondrial metabolismNADPH oxidaseOxidative stressRespiration and bioenergeticsROS emissionROS production and scavenging

Identifiers

PMID37429534
PMCPMC10528392
OpenAlexW4383646093

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.