Evidence map›Paper›PMID 37430267›Full record

Trial reportParticle and fibre toxicology2023

Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles - A randomized controlled double-blind crossover study among mild asthmatic subjects.

Karin Rosenkilde Laursen, Nichlas Vous Christensen, Frans Aa Mulder, Jörg Schullehner, Hans Jürgen Hoffmann, Annie Jensen, Peter Møller, Steffen Loft, Anna-Carin Olin, Berit B Rasmussen and 6 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Particle and fibre toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Karin Rosenkilde LaursenEnvironment, Occupation and Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Nichlas Vous ChristensenInterdisciplinary Nanoscience Centre (iNANO), Aarhus University, Aarhus, Denmark.
Frans Aa MulderInterdisciplinary Nanoscience Centre (iNANO), Aarhus University, Aarhus, Denmark.
Jörg SchullehnerEnvironment, Occupation and Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Hans Jürgen HoffmannDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Annie JensenSection of Environmental Health, Department of Public Health, University of Copenhagen, Aarhus, Denmark.
Peter MøllerSection of Environmental Health, Department of Public Health, University of Copenhagen, Aarhus, Denmark.
Steffen LoftSection of Environmental Health, Department of Public Health, University of Copenhagen, Aarhus, Denmark.
Anna-Carin OlinDepartment of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
Berit B RasmussenDepartment of Chemistry, Aarhus University, Aarhus, Denmark.
Bernadette RosatiDepartment of Chemistry, Aarhus University, Aarhus, Denmark.
Bo StrandbergDivision of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Marianne GlasiusDepartment of Chemistry, Aarhus University, Aarhus, Denmark.
Merete BildeDepartment of Chemistry, Aarhus University, Aarhus, Denmark.
Torben SigsgaardEnvironment, Occupation and Health, Department of Public Health, Aarhus University, Aarhus, Denmark. ts@ph.au.dk.
Climate Chamber Group
Aarhus University · DKUniversity of Copenhagen · DKAarhus University Hospital · DKLund University · SEUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is insufficient knowledge about the systemic health effects of exposure to fine (PM

resultsSP-A in droplets in exhaled air showed stable concentrations following candle exposure, while concentrations decreased following cooking and clean air exposure. Albumin in droplets in exhaled air increased following exposure to cooking and candles compared to clean air exposure, although not significant. Oxidatively damaged DNA and concentrations of some lipids and lipoproteins in the blood increased significantly following exposure to cooking. We found no or weak associations between cooking and candle exposure and systemic inflammation biomarkers including cytokines, CRP, and EPCs.

conclusionsCooking and candle emissions induced effects on some of the examined health-related biomarkers, while no effect was observed in others; Oxidatively damaged DNA and concentrations of lipids and lipoproteins were increased in blood after exposure to cooking, while both cooking and candle emissions slightly affected the small airways including the primary outcomes SP-A and albumin. We found only weak associations between the exposures and systemic inflammatory biomarkers. Together, the results show the existence of mild inflammation following cooking and candle exposure.

Indexed as

AsthmaAlbuminsBiomarkersCookingC-Reactive ProteinCross-Over StudiesCytokinesErythema NodosumFingersHumansInflammationLipidsAlbuminsBiomarkersC-Reactive ProteinCytokinesLipidsBiomarkersCandlesCookingHuman exposureIndoor airInflammationMetabolomicsOxidatively damaged DNASP-AUltrafine particles

Identifiers

PMID37430267
PMCPMC10332087
OpenAlexW4383737022

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.