ArticleGenome biology2023
CimpleG: finding simple CpG methylation signatures.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Ginsenosides exhibit potential therapeutic potential in photoaging by regulating keratinocyte ferroptosis.Journal of ginseng research · 2026Article
- Examining cellular heterogeneity in human DNA methylation studies: Overview and recommendations.STAR protocols · 2025Review
- MinLinMo: a minimalist approach to variable selection and linear model prediction.BMC bioinformatics · 2024Article
- Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer.Clinical epigenetics · 2024Article
- Epigenetic biomarkers to track differentiation of pluripotent stem cells.Stem cell reports · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. Here, we propose a computational framework named CimpleG for the detection of small CpG methylation signatures used for cell-type classification and deconvolution. We show that CimpleG is both time efficient and performs as well as top performing methods for cell-type classification of blood cells and other somatic cells, while basing its prediction on a single DNA methylation site per cell type. Altogether, CimpleG provides a complete computational framework for the delineation of DNAm signatures and cellular deconvolution.
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Registered trials
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