Evidence map›Paper›PMID 37431265›Full record

ArticleJournal of developmental origins of health and disease2023

Relationship between insulin and Netrin-1/DCC guidance cue pathway regulation in the prefrontal cortex of rodents exposed to prenatal dietary restriction.

Aashita Batra, Santiago Cuesta, Marcio Bonesso Alves, Jose Maria Restrepo, Michel Giroux, Daniela Pereira Laureano, Amanda Brondani Mucellini Lovato, Patrícia Maidana Miguel, Tania Diniz Machado, Roberta Dalle Molle and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of developmental origins of health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Aashita Batra *Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada.ORCID 0000-0001-8144-0064
Santiago Cuesta *Department of Cell Biology and Neuroscience, Rutgers University, New Brunswick, NJ, USA.ORCID 0000-0001-6960-9410
Marcio Bonesso AlvesLudmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada.
Jose Maria RestrepoIntegrated Program in Neuroscience, McGill University, Montreal, QC, Canada.ORCID 0000-0002-6093-6850
Michel GirouxDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Daniela Pereira LaureanoPrograma de Pós-Graduação em Saúde da Criança e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Amanda Brondani Mucellini LovatoPrograma de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Patrícia Maidana MiguelDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Tania Diniz MachadoPrograma de Pós-Graduação em Saúde da Criança e do Adolescente, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID 0000-0002-3706-4185
Roberta Dalle MolleLudmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada.
Cecilia FloresDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Patricia Pelufo SilveiraLudmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada.
Douglas Mental Health University Institute · CAUniversidade Federal do Rio Grande do Sul · BRRutgers, The State University of New Jersey · US

Funding

Amphetamine in adolescence disrupts frontal cortex developmentR01DA037911 · NIDA · MCGILL UNIVERSITY · PI FLORES, CECILIA · 2015 to 2024
$2.5M
CIHRNIDA NIH HHS R01 DA037911
6 · The paper itself

Abstract

Fetal restriction (FR) alters insulin sensitivity, but it is unknown how the metabolic profile associated with restriction affects development of the dopamine (DA) system and DA-related behaviors. The Netrin-1/DCC guidance cue system participates in maturation of the mesocorticolimbic DA circuitry. Therefore, our objective was to identify if FR modifies Netrin-1/DCC receptor protein expression in the prefrontal cortex (PFC) at birth and mRNA in adulthood in rodent males. We used cultured HEK293 cells to assess if levels of miR-218, microRNA regulator of DCC, are sensitive to insulin. To assess this, pregnant dams were subjected to a 50% FR diet from gestational day 10 until birth. Medial PFC (mPFC) DCC/Netrin-1 protein expression was measured at P0 at baseline and

Indexed as

Insulin ResistanceMicroRNAsAnimalsCuesDCC ReceptorFemaleHEK293 CellsHumansInsulinMaleNetrin-1Prefrontal CortexPregnancyRatsReceptors, Cell SurfaceRNA, MessengerDCC protein, humanDCC ReceptorInsulinMicroRNAsMIRN218 microRNA, humanNetrin-1Receptors, Cell SurfaceRNA, MessengerTumor Suppressor ProteinsAxonal guidance cuesFood restrictionInsulinIntrauterine growth restrictionMesocorticolimbic dopamine pathwayPrenatal adversity

Identifiers

PMID37431265
PMCPMC10988268
OpenAlexW4383873281

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.