Evidence map›Paper›PMID 37433004›Full record

ArticleScience signaling2023

Skewing cPLA

Kenneth D Maus, Daniel J Stephenson, H Patrick Macknight, Ngoc T Vu, L Alexis Hoeferlin, Minjung Kim, Robert F Diegelmann, Xiujie Xie, Charles E Chalfant

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Effect of ProbioticThe Malaysian journal of medical sciences : MJMS · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Differential lipid signaling from CD4Frontiers in immunology · 2024
    Article
  19. Siglec-FTheranostics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kenneth D MausDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-2868-2934
Daniel J StephensonDepartment of Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-5698-3400
H Patrick MacknightDepartment of Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0003-3232-6155
Ngoc T VuDepartment of Applied Biochemistry, School of Biotechnology, International University-VNU HCM, Ho Chi Minh City, Vietnam.
L Alexis HoeferlinDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University-School of Medicine, Richmond VA 23298, USA.ORCID 0000-0001-7569-8712
Minjung KimDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL 33620, USA.ORCID 0000-0002-5682-6640
Robert F DiegelmannDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University-School of Medicine, Richmond VA 23298, USA.ORCID 0000-0002-3876-0107
Xiujie XieDepartment of Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-3424-7939
Charles E ChalfantDepartment of Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-5844-5235
University of Virginia · USUniversity of South Florida · USVirginia Commonwealth University · USHo Chi Minh City International University · VNUnited States Department of Veterans Affairs · US

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
The roles of ceramide and its derivatives in A. phagocytophilum pathogenesisR01AI139072 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARLES E. CHALFANT, Jason A Carlyon · 2018 to 2026
$5.7M
The functional role of the cPLA2alpha/C1P interaction in sepsis resolutionR01HL125353 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RHODERICK E, CHALFANT, CHARLES E. · 2014 to 2018
$4.0M
The role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healingR01GM137394 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., KORDULA, TOMASZ K · 2021 to 2024
$1.9M
The role of ceramide kinase in mitophagyR01GM137578 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E. · 2020 to 2023
$1.3M
The role of RNA splicing in non-small cell lung cancerI01BX001792 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2013 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX004603 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2019 to 2025
–
BLRD VA I01 BX001792BLRD VA I01 BX006063BLRD VA IK6 BX004603NHLBI NIH HHS R01 HL125353NIAID NIH HHS R01 AI139072NIDDK NIH HHS U2C DK119886NIGMS NIH HHS R01 GM137394NIGMS NIH HHS R01 GM137578
6 · The paper itself

Abstract

Uncontrolled inflammation is linked to poor outcomes in sepsis and wound healing, both of which proceed through distinct inflammatory and resolution phases. Eicosanoids are a class of bioactive lipids that recruit neutrophils and other innate immune cells. The interaction of ceramide 1-phosphate (C1P) with the eicosanoid biosynthetic enzyme cytosolic phospholipase A

Indexed as

NeutrophilsSepsisAnimalsAutocrine CommunicationGroup IV Phospholipases A2InflammationMiceGroup IV Phospholipases A2

Identifiers

PMID37433004
PMCPMC10565596
OpenAlexW4383874949

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.