Evidence map›Paper›PMID 37433330›Full record

ArticleOpen biology2023

Mutant SPART causes defects in mitochondrial protein import and bioenergetics reversed by Coenzyme Q.

Chiara Diquigiovanni, Nicola Rizzardi, Antje Kampmeier, Irene Liparulo, Francesca Bianco, Bianca De Nicolo, Erica Cataldi-Stagetti, Elisabetta Cuna, Giulia Severi, Marco Seri and 8 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Open biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Metabolic Profiling of DistinctInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Biosynthesis, Deficiency, and Supplementation of Coenzyme Q.Antioxidants (Basel, Switzerland) · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Chiara DiquigiovanniDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.ORCID 0000-0003-3124-6946
Nicola RizzardiDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.
Antje KampmeierInstitut für Humangenetik, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen 45122, Germany.
Irene LiparuloDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.
Francesca BiancoDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
Bianca De NicoloDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
Erica Cataldi-StagettiDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
Elisabetta CunaDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.ORCID 0000-0003-4847-8882
Giulia SeveriIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna 40138, Italy.
Marco SeriIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna 40138, Italy.
Miriam BertrandInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen 72076, Germany.
Tobias B HaackInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen 72076, Germany.
Adela Della MarinaDepartment of Pediatric Neurology, Centre for Neuromuscular Disorders, Centre for Translational Neuro- and Behavioral Sciences, University Duisburg-Essen, Essen 45122, Germany.
Frederik BraunDepartment of Pediatric Neurology, Centre for Neuromuscular Disorders, Centre for Translational Neuro- and Behavioral Sciences, University Duisburg-Essen, Essen 45122, Germany.
Romana FatoDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.
Alma KuechlerInstitut für Humangenetik, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen 45122, Germany.
Christian BergaminiDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy.
Elena BonoraDepartment of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
Azienda USL di Bologna · ITUniversity of Bologna · ITEssen University Hospital · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants in

Indexed as

Cognitive DysfunctionUbiquinoneChild, PreschoolEnergy MetabolismHumansMaleMitochondrial ProteinsNuclear Proteinscoenzyme Q10Mitochondrial ProteinsNuclear ProteinsUbiquinonebioenergeticsCoenzyme Qmitochondrial protein importSpartinSPG20

Identifiers

PMID37433330
PMCPMC10335854
OpenAlexW4383873820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.