Evidence map›Paper›PMID 37433890›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023

STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.

Lulin Ma, Daling Deng, Tianhao Zhang, Wenjing Zhao, Chengxi Liu, Shiqian Huang, Feng Xu, Yafeng Wang, Shuai Zhao, Yuanyuan Ding and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Lulin Ma *Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Daling Deng *Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Tianhao ZhangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wenjing ZhaoDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Chengxi LiuDepartment of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, China.
Shiqian HuangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Feng XuDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yafeng WangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Shuai ZhaoDepartment of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Yuanyuan DingDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yan HuangDepartment of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Kaixin WangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yanyan ZhangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xinxin YangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Song CaoDepartment of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Xiangdong ChenDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. xiangdongchen2013@163.com.
Wuhan University · CNZhongnan Hospital of Wuhan University · CNHuazhong University of Science and Technology · CNUnion Hospital · CNUniversity of South China · CNZunyi Medical University · CN

Funding

Hubei Province Key Research and Development Program 2021BCA145National Key Research and Development Program of China 2018YFC2001802National Natural Science Foundation 82071251
6 · The paper itself

Abstract

backgroundThe purpose of this study was to study the effect of STING-IFN-I pathway on incision induced postoperative pain in rats and its possible mechanisms.

methodsThe pain thresholds were evaluated by measuring the mechanical withdrawal threshold and the thermal withdrawal latency. The satellite glial cell and macrophage of DRG were analyzed. The expression of STING, IFN-a, P-P65, iNOS, TNF-α, IL-1β and IL-6 in DRG was evaluated.

resultsThe activation of STING-IFN-I pathway can reduce the mechanical hyperalgesia, thermal hyperalgesia, down-regulate the expression of P-P65, iNOS, TNF-α, IL-1β and IL-6, and inhibit the activation of satellite glial cell and macrophage in DRG.

conclusionsThe activation of STING-IFN-I pathway can alleviate incision induced acute postoperative pain by inhibiting the activation of satellite glial cell and macrophage, which reducing the corresponding neuroinflammation in DRG.

Indexed as

Ganglia, SpinalTumor Necrosis Factor-alphaAnimalsHyperalgesiaInterleukin-6Neuroinflammatory DiseasesPostoperative PainRatsRats, Sprague-DawleyInterleukin-6Tumor Necrosis Factor-alphaAcute postoperative painMacrophageNeuroinflammationSatellite glial cellSTING-IFN-I

Identifiers

PMID37433890
OpenAlexW4383896428

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.