Evidence map›Paper›PMID 37433893›Full record

Trial reportJournal of neurology2023

Efficacy of cerebellar transcranial magnetic stimulation in spinocerebellar ataxia type 3: a randomized, single-blinded, controlled trial.

Yuting Shi, Guangdong Zou, Zhao Chen, Linlin Wan, Linliu Peng, Huirong Peng, Lu Shen, Kun Xia, Rong Qiu, Beisha Tang and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Yuting Shi *Department of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Guangdong Zou *Department of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Linlin WanKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China.
Linliu PengDepartment of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Huirong PengDepartment of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Kun XiaCenter for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
Rong QiuSchool of Computer Science and Engineering, Central South University, Changsha, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, China. jianghong73868@126.com.ORCID http://orcid.org/0000-0003-2812-4120
Central South University · CN

Funding

Health Commission of Hunan Province B2019183Innovation Research Group Project of Natural Science Foundation of Hunan Province 2020JJ1008Key Research and Development Program of Hunan Province of China 2018SK2092Key Research and Development Program of Hunan Province of China 2020SK2064Key Technologies Research and Development Program 2021YFA0805200National Natural Science Foundation of China 81901169National Natural Science Foundation of China 81974176National Natural Science Foundation of China 82171254Natural Science Foundation of Hunan Province 2021JJ40974Natural Science Foundation of Hunan Province 2022JJ20094Project Program of National Clinical Research Center for Geriatric Disorders 2020LNJJ12Project Program of National Clinical Research Center for Geriatric Disorders XYYYJSTG-05Science and Technology Innovation Group of Hunan Province 2020RC4043science and technology innovation Program of Hunan Province 2022RC1027
6 · The paper itself

Abstract

backgroundSpinocerebellar ataxia type 3 (SCA3) is the most common subtype of SCA without effective treatment. This study aimed to evaluate the comparative efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) and intermittent Theta Burst Stimulation (iTBS) in a larger cohort of SCA3 patients.

methodsOne hundred and twenty patients with SCA3 were randomly assigned to the 3 groups: 40 patients in the 1 Hz rTMS, 40 in the iTBS and 40 in the sham group. Patients underwent 10 sessions of rTMS targeting the cerebellum delivering for 5 consecutive days per week for 2 weeks (a total of 1200 pulses per session). Primary outcomes included the Scale for the Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS). Secondary outcomes included 10-m walking test (10MWT), nine-hole peg test (9-HPT), and PATA Rate Test (PRT). Outcome assessments were performed at baseline and on the last day of rTMS intervention.

resultsThis study revealed that active rTMS outperformed sham in reducing the SARA and ICARS scores in SCA3 patients, but with no difference between the 1 Hz rTMS and iTBS protocol. Moreover, no significant differences were observed in SARA and ICARS scores between the mild and moderate to severe groups after the 1 Hz rTMS/iTBS therapy. Additionally, no severe adverse events were recorded in this study.

conclusionsThe study concluded that both 1 Hz rTMS and iTBS interventions targeting the cerebellum are effective to improve the symptoms of ataxia in patients with SCA3.

Indexed as

CerebellumMachado-Joseph DiseaseOutcome Assessment, Health CareTranscranial Magnetic StimulationAdultAgedFemaleHumansMaleMiddle AgedSeverity of Illness IndexSingle-Blind MethodTreatment OutcomeAtaxiaCerebellumiTBSRepetitive transcranial magnetic stimulationSCA3

Identifiers

PMID37433893
OpenAlexW4383897140

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.