Evidence map›Paper›PMID 37433969›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2023

Predictors of successful treatment of respiratory distress with aerosolized calfactant.

Michelle Hojnicki, Henry A Zapata, Dinushan C Kaluarachchi, Prem Fort, Stephen Minton, George Albert, Ann Ross, Gregory E Wilding, Scott O Guthrie

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. High vs low CPAP strategy with aerosolized calfactant in preterm infants with respiratory distress syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Trial
  2. Less invasive surfactant administration methods: Who, what and how.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Michelle HojnickiJohns Hopkins All Children's Hospital, Maternal, Fetal and Neonatal Institute, St. Petersburg, FL, USA.
Henry A ZapataDepartment of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-9350-7326
Dinushan C KaluarachchiDepartment of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-8334-6282
Prem FortJohns Hopkins All Children's Hospital, Maternal, Fetal and Neonatal Institute, St. Petersburg, FL, USA.
Stephen MintonUtah Valley Regional Medical Center, Provo, UT, USA.
George AlbertSisters of Charity Hospital, Buffalo, NY, USA.
Ann RossDepartment of Neonatology, K Hovnanian Children's Hospital, Hackensack Meridian Health, Neptune, NJ, USA.
Gregory E WildingDepartment of Biostatistics, University at Buffalo, Buffalo, NY, USA.
Scott O GuthrieDepartment of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN, USA. scott.o.guthrie@vumc.org.ORCID 0000-0001-9703-5266
Johns Hopkins University · USUniversity of Wisconsin–Madison · USHackensack Meridian Health · USSisters of Charity Hospital · USUniversity at Buffalo, State University of New York · USUtah Valley Regional Medical Center · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPredictors for successful aerosolized surfactant treatment are not well defined.

objectiveTo identify predictors for successful treatment in the AERO-02 trial and the AERO-03 expanded access program.

methodsNeonates receiving nasal continuous positive airway pressure (NCPAP) at the time of first aerosolized calfactant administration were included in this analysis. Associations between demographic and clinical predictors to need for intubation were examined using univariate testing and multivariate logistic regression analyses.

resultsThree hundred and eighty infants were included in the study. Overall, 24% required rescue by intubation. Multivariate modeling revealed that the predictors of successful treatment were a gestational age ≥31 weeks, a respiratory severity score (RSS) of <1.9, and <2 previous aerosol treatments.

conclusionGestational age, number of aerosols, and RSS are predictive of successful treatment. These criteria will help select patients most likely to benefit from aerosolized surfactant.

Indexed as

Biological ProductsPulmonary SurfactantsRespiratory Distress Syndrome, NewbornContinuous Positive Airway PressureHumansInfant, NewbornSurface-Active AgentsBiological ProductscalfactantPulmonary SurfactantsSurface-Active Agents

Identifiers

PMID37433969
OpenAlexW4383876316

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.