Evidence map›Paper›PMID 37434796›Full record

ArticleJournal of cancer prevention2023

Baicalein Inhibits α-Melanocyte-stimulating Hormone-stimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells.

Min Chang Oh, Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Jin Won Hyun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer prevention, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Postbiotic Effects ofMicroorganisms · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Min Chang Oh *Department of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0009-0000-8763-5655
Pincha Devage Sameera Madushan Fernando *Department of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0002-8263-4706
Mei Jing PiaoDepartment of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0001-5355-1234
Kyoung Ah KangDepartment of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0002-5382-536X
Herath Mudiyanselage Udari Lakmini HerathDepartment of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0002-6343-8697
Jin Won HyunDepartment of Biochemistry, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0002-3403-3762
Jeju National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.

Indexed as

B16F10 cellsBaicaleinCarcinogenesisMonophenol monooxygenaseα-Melanocyte-stimulating hormone

Identifiers

PMID37434796
PMCPMC10331030
OpenAlexW4383315133

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.