Evidence map›Paper›PMID 37434849›Full record

ArticleAmerican journal of translational research2023

Increasing autophagy ameliorates all-

Qingqing Xia, Jie Li, Lingmin Zhang, Yingying Zhou, Zaixing Yang, Jing Xie

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qingqing XiaDepartment of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital Taizhou, Zhejiang, China.
Jie LiDepartment of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital Taizhou, Zhejiang, China.
Lingmin ZhangDepartment of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital Taizhou, Zhejiang, China.
Yingying ZhouDepartment of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital Taizhou, Zhejiang, China.
Zaixing YangDepartment of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital Taizhou, Zhejiang, China.
Jing XieDepartment of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital Taizhou, Zhejiang, China.
Taizhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSevere inflammation, mediated by innate immune sensors, can be observed in the retina and is considered to play an important role in the pathogenesis of retinal degeneration caused by all-

methodsThe cytotoxicity of atRAL in THP-1 macrophage cells was assessed using the cell counting kit-8 (CCK-8) assay, and mature IL-1β was detected by enzyme-linked immunosorbent assay (ELISA). We measured levels of NLRP3 and cleaved caspase-1 by western blotting to evaluate the activation of NLRP3 inflammasomes. Oxidative stress was validated by measuring mitochondria-associated reactive oxygen species (ROS) with MitoSOX

resultsThe maturation and release of IL-1β were regulated by the activation of the NLRP3 inflammasome. Mitochondria-associated ROS were involved in the regulation of NLRP3 inflammasome activation and caspase-1 cleavage. In addition, atRAL functionally activated autophagy in THP-1 cells, and atRAL-induced NLRP3 inflammasome activation was suppressed by autophagy.

conclusionsatRAL activates both the NLRP3 inflammasome and autophagy in THP-1 cells, and the increasing level of autophagy leads to the inhibition of excessive NLRP3 inflammasome activation. These findings shed new light on the pathogenesis of age-related retinal degeneration.

Indexed as

age-related macular degenerationAll-trans-retinalautophagyNLRP3 inflammasomereactive oxygen species

Identifiers

PMID37434849
PMCPMC10331683
OpenAlexW4383998938

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.