Evidence map›Paper›PMID 37435188›Full record

ArticleEndocrine oncology (Bristol, England)2021

Hypoxia stimulates angiogenesis and a metabolic switch in human parathyroid adenoma cells.

K E Lines, M Stevenson, R Mihai, I V Grigorieva, O A Shariq, K U Gaynor, J Jeyabalan, M Javid, R V Thakker

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine oncology (Bristol, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

K E LinesOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
M StevensonOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
R MihaiDepartment of Endocrine Surgery, Oxford University Hospitals NHS Foundation Trust, Headington, Oxford, UK.
I V GrigorievaOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
O A ShariqOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
K U GaynorOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
J JeyabalanOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
M JavidOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
R V ThakkerOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism · GBChurchill Hospital · GBOxford University Hospitals NHS Trust · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia, a primary stimulus for angiogenesis, is important for tumour proliferation and survival. The effects of hypoxia on parathyroid tumour cells, which may also be important for parathyroid autotransplantation in patients, are, however, unknown. We, therefore, assessed the effects of hypoxia on gene expression in parathyroid adenoma (PA) cells from patients with primary hyperparathyroidism. Cell suspensions from human PAs were cultured under normoxic or hypoxic conditions and then subjected to cDNA expression analysis. In total, 549 genes were significantly upregulated and 873 significantly downregulated. The most highly upregulated genes (carbonic anhydrase 9 (

Indexed as

glycolysisgrowth factor signallinghypoxicmetabolic switch

Identifiers

PMID37435188
PMCPMC10265544
OpenAlexW3184785063

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.