Evidence map›Paper›PMID 37435649›Full record

ArticlePsychological medicine2023

The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis.

Anne-Sophie D Enthoven, Shiral S Gangadin, Lieuwe de Haan, Wim Veling, Erik F J de Vries, Janine Doorduin, HAMLETT and OPHELIA Consortium, Marieke J H Begemann, Iris E C Sommer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Sex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anne-Sophie D EnthovenDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-7268-2950
Shiral S GangadinDepartment of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lieuwe de HaanDepartment of Early Psychosis, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands.
Wim VelingDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Erik F J de VriesDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Janine DoorduinDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
HAMLETT and OPHELIA Consortium
Marieke J H BegemannDepartment of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iris E C SommerDepartment of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLAmsterdam UMC Location University of Amsterdam · NL

Funding

ZonMw 80-84800-98-41015
6 · The paper itself

Abstract

backgroundChildhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In a large sample of recent-onset patients, we investigated the associations of depressive and negative symptoms with childhood trauma and whether these are sex-specific.

methodsA total of 187 first-episode psychosis patients in remission (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment study) and 115 recent-onset SSD patients (Simvastatin study) were included in this cross-sectional study (men:

resultsWomen reported higher rates of sexual abuse than men (23.5%

conclusionsDepressive symptom severity was associated with different types of trauma in men and women with recent-onset SSD. Specifically, in women, depressive symptom severity was associated with childhood sexual abuse, which was reported three times as often as in men. Our results emphasize the importance of sex-specific analyses in SSD research.

Indexed as

Adverse Childhood ExperiencesPsychotic DisordersSchizophreniaCross-Sectional StudiesFemaleHumansMalePsychological TestsSelf ReportChildhood traumadepressive symptomsfirst-episode psychosisnegative symptomspsychosisschizophreniasex

Identifiers

PMID37435649
PMCPMC10755234
OpenAlexW4383998817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.