Evidence mapPaperPMID 37435906Full record

ArticleAmerican journal of hematology2023

Increased transferrin protects from thrombosis in Chuvash erythrocytosis.

Binal N Shah, Xu Zhang, Adelina I Sergueeva, Galina Y Miasnikova, Tomas Ganz, Josef T Prchal, Victor R Gordeuk

Open access · hybridAbstract read
In one paragraph

Article in American journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Binal N ShahDivision of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0001-5169-7301
Xu ZhangDivision of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0002-7732-1385
Adelina I SergueevaDepartment of Pediatric Oncology and Hematology, N. Ulianov Chuvash State University, Cheboksary, Chuvashia, Russia.
Galina Y MiasnikovaDepartment of Hematology and Chemotherapy, Chuvash Republic Clinical Hospital, Cheboksary, Chuvashia, Russia.
Tomas GanzPathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-2830-5469
Josef T PrchalDepartment of Medicine, University of Utah, VAH, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.ORCID 0000-0002-8019-2940
Victor R GordeukDivision of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID 0000-0003-4725-7295
University of Illinois Chicago · USChuvash State University · RUUniversity of California, Los Angeles · USUniversity of Utah · US

Funding

Project 4: MPN Clinical ConsortiumP01CA108671 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$4.0M
Pulmonary Hypertension and the Hypoxic Response in SCDR01HL079912 · HOWARD UNIVERSITY · 2005 to 2005
$1.9M
Howard University Research Scientist AwardR25HL003679 · HOWARD UNIVERSITY · 2005 to 2005
$432k
NCI NIH HHS P01 CA108671NHLBI NIH HHS P50 HL118006NHLBI NIH HHS R01 HL079912NHLBI NIH HHS R01 HL137991NHLBI NIH HHS R25 HL003679NHLBI NIH HHS U10 HL083748NHLBI NIH HHS U54 HL090508
6 · The paper itself

Abstract

Von Hippel-Lindau protein (VHL) is essential to hypoxic regulation of cellular processes. VHL promotes proteolytic clearance of hypoxia-inducible transcription factors (HIFs) that have been modified by oxygen-dependent HIF-prolyl hydroxylases. A homozygous loss-of-function VHL

Indexed as

ErythropoietinIron DeficienciesPolycythemiaThrombosisFerritinsHumansHypoxiaTransferrinVon Hippel-Lindau Tumor Suppressor ProteinErythropoietinFerritinsTransferrinVon Hippel-Lindau Tumor Suppressor Protein

Identifiers

PMID37435906
PMCPMC10529798
OpenAlexW4383998512

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.