ArticleCell metabolism2023
Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice.
Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis.Aging cell · 2025Pooled it
- Circulating factors induced by time-restricted eating drive metabolic reprogramming in endothelial cells.GeroScience · 2026Article
- Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.Nature aging · 2026Article
- Reducing the strain on calorie restriction.Life metabolism · 2026Article
- Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice.GeroScience · 2026Article
- A Critical Assessment of Fasting to Promote Metabolic Health and Longevity.Endocrine reviews · 2025Review
- Time-Restricted Feeding Extends Healthspan in Female and Lifespan in Male C57BL/6J Mice.bioRxiv : the preprint server for biology · 2025Article
- Intermittent fasting attenuates glial hyperactivation and photoreceptor degeneration in a NaIOCommunications biology · 2025Article
- Calorie-restriction treatment mitigates the aging in rat liver model.Biogerontology · 2025Article
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- Pu-erh tea attenuates obesity by remodeling gut microbiota and activating energy expenditure.Frontiers in microbiology · 2025Article
- Health effects of intermittent fasting and the role of artificial intelligence technologies in optimizing its clinical translation.AIMS public health · 2025Review
- Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase.Obesity (Silver Spring, Md.) · 2024Article
- Geroprotective effects of GdVOBiogerontology · 2024Article
- Dietary nitrate maintains intestinal epithelia homeostasis in aged mice.Biogerontology · 2024Article
- Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice.Nature communications · 2024Article
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17 authors at 2 institutions in 1 country.
Funding
Abstract
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old female mice on five different dietary regimens, either CR or TRF with different feeding windows, and determined the effects of these regimens on physiological responses, progression of neoplasms and inflammatory diseases, serum metabolite levels, and lifespan. Compared with TRF feeding, CR elicited a robust systemic response, as it relates to energetics and healthspan metrics, a unique serum metabolomics signature in overnight fasted animals, and was associated with an increase in lifespan. These results indicate that daytime (rest-phase) feeding with prolonged fasting periods initiated late in life confer greater benefits when combined with imposed lower energy intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.