ReviewInternational wound journal2023
Preclinical study of diabetic foot ulcers: From pathogenesis to vivo/vitro models and clinical therapeutic transformation.
Review in International wound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Mouse models of diabetes-related ulcers: a systematic review and network meta-analysis.EBioMedicine · 2023Pooled it
- Electrospun Membranes for Diabetic Wound Healing: Advances, Challenges, and Future Directions.Advanced healthcare materials · 2026Review
- Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms.Gels (Basel, Switzerland) · 2026Review
- Integrated multi-technology exploration of the mechanism by which Badushengji San regulates core targets in diabetic foot ulcer.Molecular genetics and genomics : MGG · 2026Article
- Phase-engineered MoSJournal of nanobiotechnology · 2026Article
- [Mechanism of actions and reflections of Masquelet induced membrane technique in diabetic wound].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Bridging Hypoxia and Vision Loss: The Emerging Role of Connexins in Local and Systemic Eye Diseases.International journal of molecular sciences · 2026Review
- Efficacy and safety of external phytotherapy in diabetic foot ulcers: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.Diabetology & metabolic syndrome · 2026Review
- Risk factors for diabetic at-risk foot disease among the diabetes over 60 years old: a cross-sectional study.Frontiers in medicine · 2026Article
- Bio-enhanced silk fibroin-based scaffolds for chronic diabetic foot ulcers.Burns & trauma · 2026Review
- Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Nanodelivery of Gentiopicroside for Inflammatory Skin Lesions: Insights from Psoriasis and Diabetic Foot Ulcers.International journal of nanomedicine · 2026Review
- miR-191-5p inhibits angiogenesis in diabetic foot ulcers wound healing via regulating VEGFA.European journal of medical research · 2025Article
- Mechanisms of lncRNA in Diabetic Foot Ulcer Wound Healing.The journal of gene medicine · 2025Review
- Distinct cytokine profiles associated with malnutrition, dyslipidemia and kidney dysfunction in patients with diabetic foot ulcer.Scientific reports · 2025Article
- Geopropolis fromMetabolites · 2025Article
- Phage therapy: a promising approach forJournal of virology · 2025Review
- Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers.Biology direct · 2025Article
- Optimizing risk management for post-amputation wound complications in diabetic patients: Focus on glycemic and immunosuppressive control.World journal of diabetes · 2025Article
- The landscape of biofilm models for phage therapy: mimicking biofilms in diabetic foot ulcers using 3D models.Frontiers in microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Diabetic foot ulcer (DFU), a common intractable chronic complication of diabetes mellitus (DM), has a prevalence of up to 25%, with more than 17% of the affected patients at risk of amputation or even death. Vascular risk factors, including vascular stenosis or occlusion, dyslipidemia, impaired neurosensory and motor function, and skin infection caused by trauma, all increase the risk of DFU in patients with diabetes. Therefore, diabetic foot is not a single pathogenesis. Preclinical studies have contributed greatly to the pathogenesis determination and efficacy evaluation of DFU. Many therapeutic tools are currently being investigated using DFU animal models for effective clinical translation. However, preclinical animal models that completely mimic the pathogenesis of DFU remain unexplored. Therefore, in this review, the preparation methods and evaluation criteria of DFU animal models with three major pathological mechanisms: neuropathy, angiopathy and DFU infection were discussed in detail. And the advantages and disadvantages of various DFU animal models for clinical sign simulation. Furthermore, the current status of vitro models of DFU and some preclinical studies have been transformed into clinical treatment programs, such as medical dressings, growth factor therapy, 3D bioprinting and pre-vascularization, Traditional Chinese Medicine treatment. However, because of the complexity of the pathological mechanism of DFU, the clinical transformation of DFU model still faces many challenges. We need to further optimize the existing preclinical studies of DFU to provide an effective animal platform for the future study of pathophysiology and clinical treatment of DFU.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.