Evidence map›Paper›PMID 37439412›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer.

Chao Tang, Mengying Ke, Xichao Yu, Shanliang Sun, Xian Luo, Xin Liu, Yanyan Zhou, Ze Wang, Xing Cui, Chunyan Gu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Gut-derivedmSystems · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. SAE1 promotes tumor cell malignancyActa pharmaceutica Sinica. B · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chao TangNanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Mengying KeSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Xichao YuSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Shanliang SunSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Xian LuoSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Xin LiuSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Yanyan ZhouSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Ze WangSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Xing CuiDepartment of Hematology and Oncology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250001, China.
Chunyan GuNanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China.
Ye YangSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.ORCID 0000-0003-0228-5102
Nanjing University of Chinese Medicine · CNShandong University of Traditional Chinese Medicine · CN

Funding

Jiangsu Postgraduate Research and Practice Innovation Program KYCX22_1997National Key R&D Program of China 2020YFA0509400National Natural Science Foundation of China 82104265Priority Academic Program Development of Jiangsu Higher Education Institutions
6 · The paper itself

Abstract

Tumor stemness is associated with the recurrence and incurability of colorectal cancer (CRC), which lacks effective therapeutic targets and drugs. Glycinamide ribonucleotide transformylase (GART) fulfills an important role in numerous types of malignancies. The present study aims to identify the underlying mechanism through which GART may promote CRC stemness, as to developing novel therapeutic methods. An elevated level of GART is associated with poor outcomes in CRC patients and promotes the proliferation and migration of CRC cells. CD133

Indexed as

Carbon-Nitrogen LigasesColorectal NeoplasmsATPases Associated with Diverse Cellular Activitiesbeta CateninCarrier ProteinsCell Line, TumorDNA HelicasesHumansMethyltransferasesPhosphoribosylglycinamide FormyltransferaseWnt Signaling PathwayATPases Associated with Diverse Cellular Activitiesbeta CateninCarbon-Nitrogen LigasesCarrier ProteinsDNA HelicasesGART protein, humanMethyltransferasesPhosphoribosylglycinamide FormyltransferaseRUVBL1 protein, humancancer stem cellscolorectal cancerglycinamide ribonucleotide transformylasepemetrexedRUVBL1/β-catenin axis

Identifiers

PMID37439412
PMCPMC10477903
OpenAlexW4384126869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.