Evidence map›Paper›PMID 37439845›Full record

ArticleHandbook of experimental pharmacology2023

Intersection of Sex and Depression: Pathogenesis, Presentation, and Treatments.

Dafni F T Frohman, Kimberly Nnah, Stella E Tsirka

Open access · greenAbstract read
In one paragraph

Article in Handbook of experimental pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Psychological Distress, Resilience, and Immunoinflammatory Signatures in Healthcare Workers During COVID-19.Stress and health : journal of the International Society for the Investigation of Stress · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dafni F T FrohmanRenaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Kimberly NnahRenaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Stella E TsirkaRenaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA. styliani-anna.tsirka@stonybrook.edu.
Stony Brook University · USStony Brook School · US

Funding

A translational study of neuroinflammatory depression: Understanding mechanism and evaluation of a novel pharmacologic intervention - Diversity Administrative supplement for Kimberly NnahR01MH123093 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI DELORENZO, CHRISTINE, PARSEY, RAMIN V. · 2020 to 2024
$3.8M
IMSD at Stony Brook University: Maximizing Excellence in Research for Graduate Education -- Fostering Inclusive Research Scientist Training (FIRST)T32GM135746 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI GERGEN, JOHN PETER · 2021 to 2025
$2.3M
NIGMS NIH HHS T32 GM135746NIMH NIH HHS R01 MH123093
6 · The paper itself

Abstract

Major Depressive Disorder (MDD) is a highly prevalent, debilitating disorder. According to the World Health Organization, approximately 5% of adults suffer from depression worldwide and more women than men are affected. Yet, we have a very limited understanding of the pathogenesis of the disease, how sex and genetics influence the pathophenotype of MDD, and how they contribute to the responses to pharmacological treatment. This chapter addresses key theories about the etiology of depression, the variations in epidemiology and presentation, and the treatment options with respect to sex and gender. Additionally, we discuss the emerging wave of treatment modalities, diagnosis, and research focusing on MDD.

Indexed as

Animal modelsGeneticsHormonesInflammationMajor depression disorderMonoamine hypothesisSexual dimorphism

Identifiers

PMID37439845
PMCPMC11519624
OpenAlexW4384119845

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.