Evidence map›Paper›PMID 37439859›Full record

ArticleActa diabetologica2023

Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations.

Danielle L Jones, Clive J Petry, Keith Burling, Peter Barker, Elizabeth H Turner, Laura C Kusinski, Claire L Meek

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Danielle L JonesMetabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-0372-5579
Clive J PetryMetabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-6642-9825
Keith BurlingNIHR Biomedical Research Centre Core Biochemistry Assay Lab, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-0109-7751
Peter BarkerNIHR Biomedical Research Centre Core Biochemistry Assay Lab, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Elizabeth H TurnerMetabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.
Laura C KusinskiMetabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.
Claire L MeekMetabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK. clm70@cam.ac.uk.ORCID http://orcid.org/0000-0002-4176-8329
University of Cambridge · GBWellcome/MRC Institute of Metabolic Science · GB

Funding

Diabetes UK DUK-HKF 17/0005712
6 · The paper itself

Abstract

aimsIncretin hormones glucagon-like peptide 1 (GLP-1) and gastric inhibitory peptide (GIP) cause increased insulin secretion in non-pregnant adults, but their role in pregnancy, where there are additional metabolically-active hormones from the placenta, is less clear. The aim of the present study was to assess if fasting and post-load incretin concentrations were predictive of pregnancy insulin and glucose concentrations.

methodsPregnant women (n = 394) with one or more risk factors for gestational diabetes were recruited at 28 weeks for a 75 g oral glucose tolerance test (OGTT). Glucose, insulin, GLP-1 and GIP were measured in the fasting state and 120 min after glucose ingestion.

resultsFasting plasma GLP-1 concentrations were associated with plasma insulin (standardised β' 0.393 (0.289-0.498), p = 1.3 × 10

conclusionsThese results suggest that the relationship between insulin and incretins is preserved in pregnancy, but that other factors, such as placental hormones or counter-regulatory hormones, may be more important determinants of glycaemia and gestational diabetes aetiology.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2AdultBlood GlucoseFemaleGastric Inhibitory PolypeptideGlucagon-Like Peptide 1GlucoseHumansIncretinsInsulinPlacentaPregnancyBlood GlucoseGastric Inhibitory PolypeptideGlucagon-Like Peptide 1GlucoseIncretinsInsulinGestational diabetesIncretinInsulin secretionInsulin sensitivityObesity

Identifiers

PMID37439859
PMCPMC10587288
OpenAlexW4384120256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.