Evidence map›Paper›PMID 37442250›Full record

ArticleBrain research2023

Differential roles of diacylglycerol lipase (DAGL) enzymes in nicotine withdrawal.

Belle Buzzi, Eda Koseli, Yasmin Alkhlaif, Abigail Parker, Mohammed A Mustafa, Aron H Lichtman, Matthew W Buczynski, M Imad Damaj

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Belle BuzziDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Eda KoseliDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Yasmin AlkhlaifDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Abigail ParkerDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Mohammed A MustafaDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Aron H LichtmanDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA.
Matthew W BuczynskiSchool of Neuroscience, Virginia Polytechnic and State University, Blacksburg, VA, USA.
M Imad DamajDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Richmond, VA, USA.
Virginia Commonwealth University · USVirginia Tech · US

Funding

THE ROLE OF ENDOGENOUS OPIOIDS IN SUDDEN INFANT DEATHP50DA005274 · VIRGINIA COMMONWEALTH UNIVERSITY · 1988 to 2005
$9.0M
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · VIRGINIA COMMONWEALTH UNIVERSITY · 1985 to 2025
$4.0M
Anti-nociceptive actions of CART II in chemotherapy-induced peripheral neuropathyR01CA284075 · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2025 to 2025
$357k
NCI NIH HHS R01 CA284075NIDA NIH HHS P30 DA033934NIDA NIH HHS P50 DA005274NIDA NIH HHS T32 DA007027
6 · The paper itself

Abstract

Nicotine and tobacco-related deaths remains a leading cause of preventable death and disease in the United States. Several studies indicate that modulation of the endocannabinoid system, primarily of the endocannabinoid 2-Arachidonoylglycerol (2-AG), alters nicotinic dependence behaviors in rodents. This study, using transgenic knock-out (KO) mice, evaluated the role of the two 2-AG biosynthesis enzymes, (Diacylglycerol lipase-α) DAGL-α and DAGL-β in spontaneous nicotine withdrawal. DAGL-α deletion prevents somatic and affective signs of nicotine withdrawal, while DAGL-β deletion plays a role in hyperalgesia due to nicotine withdrawal. These results suggest a differential role of these enzymes in the various signs of nicotine withdrawal. Our behavioral findings relate to the distribution of these enzymes with DAGL-β being highly expressed in macrophages and DAGL-α in neurons. This study offers new potential targets for smoking cessation therapies.

Indexed as

Substance Withdrawal SyndromeTobacco Use DisorderAnimalsEndocannabinoidsLipoprotein LipaseMiceMice, KnockoutNicotineEndocannabinoidsLipoprotein LipaseNicotineDiacylglycerol lipaseEndocannabinoidsMiceNicotine withdrawal

Identifiers

PMID37442250
PMCPMC10529956
OpenAlexW4383879211

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.