Evidence map›Paper›PMID 37442808›Full record

ReviewBritish journal of pharmacology2024

Exploring bias in platelet P2Y

Dingxin Pan, Graham Ladds, Khondaker Miraz Rahman, Simon C Pitchford

Abstract readReview
In one paragraph

Review in British journal of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Advances in nucleotide-based P2Y₁ antagonism: implications for cardiovascular therapeutics.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Review
  3. Review
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  6. Review
  7. Review
  8. Exploring bias in platelet P2YBritish journal of pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dingxin PanSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.
Graham LaddsDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Khondaker Miraz RahmanChemical Biology Group, Institute of Pharmaceutical Science, King's College London, London, UK.ORCID 0000-0001-8566-8648
Simon C PitchfordSackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.ORCID 0000-0003-3961-0407

Funding

Medical Research Council MR/T015845/1
6 · The paper itself

Abstract

Platelets are necessary for maintaining haemostasis. Separately, platelets are important for the propagation of inflammation during the host immune response against infection. The activation of platelets also causes inappropriate inflammation in various disease pathologies, often in the absence of changes to haemostasis. The separate functions of platelets during inflammation compared with haemostasis are therefore varied and this will be reflected in distinct pathways of activation. The activation of platelets by the nucleotide adenosine diphosphate (ADP) acting on P2Y

Indexed as

Blood PlateletsPlatelet AggregationAdenosine DiphosphateHumansInflammationPlatelet ActivationReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12Signal TransductionAdenosine DiphosphateReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12aggregationbiased agonismchemotaxishaemostasisinflammationP2Y1platelets

Identifiers

PMID37442808
PMCPMC10952580

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.