Evidence map›Paper›PMID 37442881›Full record

Observational studyJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2023

Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium.

Elissa M Downs, Anne Eaton, Piotr Witkowski, Martin Wijkstrom, Matthew Walsh, Guru Trikudanathan, Vikesh K Singh, Sarah J Schwarzenberg, Timothy L Pruett, Andrew Posselt and 14 more

Open access · greenAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 16 institutions in 1 country.

Elissa M DownsDepartment of Pediatrics, University of Minnesota & Masonic Children's Hospital, 2450 Riverside Ave, Minneapolis, MN, AOB20155454, USA. down0015@umn.edu.ORCID http://orcid.org/0000-0001-5145-6903
Anne EatonDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Piotr WitkowskiDepartment of Surgery, University of Chicago, Chicago, IL, USA.
Martin WijkstromDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Matthew WalshDepartment of Surgery, Cleveland Clinic, Cleveland, OH, USA.
Guru TrikudanathanDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Vikesh K SinghDepartment of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Sarah J SchwarzenbergDepartment of Pediatrics, University of Minnesota & Masonic Children's Hospital, 2450 Riverside Ave, Minneapolis, MN, AOB20155454, USA.
Timothy L PruettDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Andrew PosseltDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Bashoo NaziruddinIslet Cell Processing Laboratory, Baylor Health, Dallas, TX, USA.
Jaimie D NathanDepartment of Pediatric Abdominal Transplant and Hepatopancreatobiliary Surgery, Nationwide Children's Hospital, Columbus, OH, USA.
Sri Prakash MokshagundamDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Katherine MorganDepartment of Surgery, The Medical University of South Carolina, Charleston, SC, USA.
Luis F LaraDepartment of Medicine, The Ohio State Wexner University Medical Center, Columbus, OH, USA.
Timothy B GardnerDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Martin L FreemanDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Kate ElleryDepartment of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Srinath ChinnakotlaDepartment of Pediatrics, University of Minnesota & Masonic Children's Hospital, 2450 Riverside Ave, Minneapolis, MN, AOB20155454, USA.
Gregory J BeilmanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
David AdamsDepartment of Surgery, The Medical University of South Carolina, Charleston, SC, USA.
Syed AhmadDepartment of Surgery, University of Cincinnati, Cincinnati, OH, USA.
Maisam Abu-El-HaijaDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Melena D BellinDepartment of Pediatrics, University of Minnesota & Masonic Children's Hospital, 2450 Riverside Ave, Minneapolis, MN, AOB20155454, USA.
University of Minnesota Medical Center · USMedical University of South Carolina · USUniversity of Minnesota Children's Hospital · USUniversity of Pittsburgh Medical Center · USBaylor Scott & White Health · USCincinnati Children's Hospital Medical Center · USCleveland Clinic · USDartmouth–Hitchcock Medical Center · USJohns Hopkins University · USNationwide Children's Hospital · USThe Ohio State University Wexner Medical Center · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Cincinnati · USUniversity of Louisville · USUniversity of Minnesota · US

Funding

Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIATR01DK109124 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2016 to 2021
$4.0M
NIDDK NIH HHS R01 DK109124NIDDK NIH HHS R01-DK109124
6 · The paper itself

Abstract

BACKGROUND AND

aimsTotal pancreatectomy with islet autotransplantation (TPIAT) can relieve pain for individuals with acute recurrent or chronic pancreatitis. However, TPIAT may increase the risk of poor nutritional status with complete exocrine pancreatic insufficiency, partial duodenectomy, and intestinal reconstruction. Our study's objective was to evaluate nutritional status, anthropometrics, and vitamin levels before and after TPIAT.

methodsThe multicenter Prospective Observational Study of TPIAT (POST) collects measures including vitamins A, D, and E levels, pancreatic enzyme dose, and multivitamin (MVI) administration before and 1-year after TPIAT. Using these data, we studied nutritional and vitamin status before and after TPIAT.

results348 TPIAT recipients were included (68% adult, 37% male, 93% Caucasian). In paired analyses at 1-year follow-up, vitamin A was low in 23% (vs 9% pre-TPIAT, p < 0.001); vitamin E was low in 11% (vs 5% pre-TPIAT, p = 0.066), and 19% had vitamin D deficiency (vs 12% pre-TPIAT, p = 0.035). Taking a fat-soluble multivitamin (pancreatic MVI) was associated with lower risk for vitamin D deficiency (p = 0.002). Adults were less likely to be on a pancreatic MVI at follow-up (34% vs 66% respectively, p < 0.001). Enzyme dosing was adequate. More adults versus children were overweight or underweight pre- and post-TPIAT. Underweight status was associated with vitamin A (p = 0.014) and E (p = 0.02) deficiency at follow-up.

conclusionsPrevalence of fat-soluble vitamin deficiencies increased after TPIAT, especially if underweight. We strongly advocate that all TPIAT recipients have close post-operative nutritional monitoring, including vitamin levels. Pancreatic MVIs should be given to minimize risk of developing deficiencies.

Indexed as

Islets of Langerhans TransplantationPancreatitis, ChronicAdultChildFemaleHumansMalePancreatectomyThinnessTransplantation, AutologousVitamin AVitaminsVitamin AVitaminsFat-soluble vitamin deficienciesPancreatitisSupplementationUnderweight

Identifiers

PMID37442881
PMCPMC11335039
OpenAlexW4384155521

What Socratic holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.