Evidence map›Paper›PMID 37443176›Full record

ArticleNPJ vaccines2023

Memory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children.

Dmitri Kazmin, Elizabeth A Clutterbuck, Giorgio Napolitani, Amanda L Wilkins, Andrea Tarlton, Amber J Thompson, Emmanuele Montomoli, Guilia Lapini, Smiti Bihari, Rachel White and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Dmitri Kazmin *Institute for Immunology, Transplantation and Infection, Stanford University, Stanford, CA, USA. dkazmin@stanford.edu.
Elizabeth A Clutterbuck *Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Giorgio Napolitani *Medical Research Council (MRC), Human Immunology Unit, University of Oxford, Oxford, UK.
Amanda L Wilkins *Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Andrea TarltonMedical Research Council (MRC), Human Immunology Unit, University of Oxford, Oxford, UK.
Amber J ThompsonOxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Emmanuele MontomoliVisMederi Srl, Via Fiorentina, Siena, Italy.
Guilia LapiniVisMederi Srl, Via Fiorentina, Siena, Italy.
Smiti BihariOxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Rachel WhiteOxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Claire JonesOxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Matthew D SnapeOxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Ushma GalalNuffield Department of Primary Care Health Sciences, Clinical Trials Unit, University of Oxford, Oxford, UK.
Ly-Mee YuNuffield Department of Primary Care Health Sciences, Clinical Trials Unit, University of Oxford, Oxford, UK.
Rino RappuoliGlaxoSmithKline, Siena, Italy.
Giuseppe Del GiudiceGlaxoSmithKline, Siena, Italy.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK. andrew.pollard@paediatrics.ox.ac.uk.ORCID http://orcid.org/0000-0001-7361-719X
Bali PulendranInstitute for Immunology, Transplantation and Infection, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.ORCID http://orcid.org/0000-0001-6517-4333
University of Oxford · GBGlaxoSmithKline (Italy) · ITEmory Healthcare · USRoyal Children's Hospital · AUStanford Medicine · USUniversity of Siena · ITVisMederi Research · IT

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI BALI PULENDRAN · 2022 to 2026
$13.2M
NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI167903
6 · The paper itself

Abstract

The pediatric population receives the majority of vaccines globally, yet there is a paucity of studies on the transcriptional response induced by immunization in this special population. In this study, we performed a systems-level analysis of immune responses to the trivalent inactivated influenza vaccine adjuvanted with MF-59 in children (15-24 months old) and in young, healthy adults. We analyzed transcriptional responses elicited by vaccination in peripheral blood, as well as cellular and antibody responses following primary and booster vaccinations. Our analysis revealed that primary vaccination induced a persistent transcriptional signature of innate immunity; booster vaccination induced a transcriptional signature of an enhanced memory-like innate response, which was consistent with enhanced activation of myeloid cells assessed by flow cytometry. Furthermore, we identified a transcriptional signature of type 1 interferon response post-booster vaccination and at baseline that was correlated with the local reactogenicity to vaccination and defined an early signature that correlated with the hemagglutinin antibody titers. These results highlight an adaptive behavior of the innate immune system in evoking a memory-like response to secondary vaccination and define molecular correlates of reactogenicity and immunogenicity in infants.

Identifiers

PMID37443176
PMCPMC10344887
OpenAlexW4384203479

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.