ArticleInternational journal of obesity (2005)2023
Long-term aspartame and saccharin intakes are related to greater volumes of visceral, intermuscular, and subcutaneous adipose tissue: the CARDIA study.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Effects of Artificial Sweeteners on the Musculoskeletal System: A Systematic Review of Current Evidence.Nutrients · 2025Pooled it
- Long-term artificial sweetener exposure increases the risk of atherosclerosis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes.BMC medicine · 2026Review
- Re-evaluation of sucralose (E 955) as a food additive and evaluation of a new application on extension of use of sucralose (E 955) in fine bakery wares.EFSA journal. European Food Safety Authority · 2026Article
- Food additives in Latin America: a descriptive analysis of the packaged food supply in five countries.Globalization and health · 2025Article
- No Evidence of Metabolomic Disruptions From Real-World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study.Journal of diabetes · 2025Article
- Urinary excretion of low- and no-calorie sweeteners (LNCS) and associated food sources, as observed in the German cross-sectional KarMeN-study.European journal of nutrition · 2025Article
- Associations of Pesticide Residue Exposure from Fruit and Vegetable Intake with Ovarian Reserve.The Journal of nutrition · 2025Article
- Sweet or sour? A review of the Aspartame market landscape, carcinogenicity, and its socioeconomic impact.Journal of food science and technology · 2025Review
- Serum Metabolomic Markers of Artificially Sweetened Beverage Consumption.The Journal of nutrition · 2024Article
- Re-evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives.EFSA journal. European Food Safety Authority · 2024Article
- Artificially sweetened beverages consumption and risk of obesity-related cancers: a wide-angled Mendelian randomization study.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundArtificial sweetener (ArtSw) intakes have been previously associated with higher BMI in observational studies and may promote visceral and skeletal muscle adipose tissue (AT) accumulation. This study aimed to determine whether habitual, long-term ArtSw or diet beverage intakes are related to greater AT depot volumes and anthropometry-related outcomes.
methodsA validated diet history questionnaire was administered at baseline, year 7, and year 20 examinations in 3088 men and women enrolled in the Coronary Artery Risk Development in Young Adults cohort (CARDIA), mean age of 25.2 years and mean BMI of 24.5 kg/m
resultsTotal ArtSw, aspartame, saccharin, and diet beverage intakes were positively associated with VAT, SAT, and IMAT volumes (all p
conclusionsResults suggest that long-term intakes of aspartame, saccharin, or diet soda may increase AT deposition and risk of incident obesity independent of diet quality or caloric intake. Coupled with previous evidence, alternatives to national recommendations to replace added sugar with ArtSw should be considered since both may have health consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.