ReviewScientific reports2023
A longitudinal transcriptomic analysis from unfed to post-engorgement midguts of adult female Ixodes scapularis.
Review in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 19 citations in OpenAlex.
- Hidden caveats in tick dissection: engorgement level and complex tracheal network architecture compromise internal organ integrity.Journal of insect science (Online) · 2026Article
- Genome-wide CRISPR knockout cell screening platform for the disease vector tick speciesbioRxiv : the preprint server for biology · 2026Article
- Langat Virus Infection Can Be Demonstrated in Both Tick Salivary Glands and Midgut Within 24 Hours of Blood Feeding.Viruses · 2026Article
- Genome sequencing and multi-stage, blood-feeding, and tissue-specific transcriptome atlas of the Rocky Mountain wood tick provide a critical resource for this vector.bioRxiv : the preprint server for biology · 2026Article
- Transcriptome of Coxiella-like endosymbionts in Haemaphysalis longicornis during blood feeding.The Journal of veterinary medical science · 2026Article
- An insight into the ovary and midgut transcriptome of Dermacentor nitens tick.Ticks and tick-borne diseases · 2026Article
- IxsS7: A novel biomarker for Ixodes scapularis tick bite exposure in humans.Ticks and tick-borne diseases · 2025Article
- An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont.BMC genomics · 2025Article
- Functional annotation and analysis of the hard tick Dermacentor nuttalli midgut genes.Parasitology research · 2025Article
- Multi-Omics Technologies Applied to Improve Tick Research.Microorganisms · 2025Review
- The hypusine pathway inFrontiers in cellular and infection microbiology · 2025Article
- The Tick Microbiome: The "Other Bacterial Players" in Tick Biocontrol.Microorganisms · 2024Review
- A multi-omics approach for understanding blood digestion dynamics in Ixodes scapularis and identification of anti-tick vaccine targets.Ticks and tick-borne diseases · 2024Article
- Exploring the longitudinal expression dynamics of midguts in adult female Amblyomma americanum ticks.BMC genomics · 2024Article
- Exploring midgut expression dynamics: longitudinal transcriptomic analysis of adult femalebioRxiv : the preprint server for biology · 2024Article
- Hard Ticks as Vectors: The Emerging Threat of Tick-Borne Diseases in India.Pathogens (Basel, Switzerland) · 2024Review
- A longitudinal transcriptomic analysis of Rhipicephalus microplus midgut upon feeding.Ticks and tick-borne diseases · 2024Article
- The immune factors involved in the rapid clearance of bacteria from the midgut of the tickFrontiers in cellular and infection microbiology · 2024Article
- Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome.Molecular & cellular proteomics : MCP · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The hematophagy behavior has evolved independently several times within the Arthropoda phylum. Interestingly, the process of acquiring a blood meal in ticks is considerably distinct from that observed in other blood-feeding arthropods. Instead of taking seconds to minutes to complete a blood meal, an adult female Ixodes scapularis tick can remain attached to its host for numerous days. During this extended feeding period, the tick undergoes drastic morphological changes. It is well established that the tick midgut plays a pivotal role not only in blood meal digestion but also in pathogen acquisition and transmission. However, our understanding of the underlying molecular mechanisms involved in these events remains limited. To expedite tick research, we conducted a comprehensive longitudinal RNA-sequencing of the tick midgut before, during, and after feeding. By collecting ticks in different feeding stages (unfed, slow feeding, rapid feeding, and early post-detached), we obtained a comprehensive overview of the transcripts present in each stage and the dynamic transcriptional changes that occur between them. This provides valuable insights into tick physiology. Additionally, through unsupervised clustering, we identified transcripts with similar patterns and stage-specific sequences. These findings serve as a foundation for selecting targets in the development of anti-tick control strategies and facilitate a better understanding of how blood feeding and pathogen infection impact tick physiology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.