Evidence map›Paper›PMID 37445713›Full record

ArticleInternational journal of molecular sciences2023

Enhanced ZBTB16 Levels by Progestin-Only Contraceptives Induces Decidualization and Inflammation.

Sefa Arlier, Umit A Kayisli, Nihan Semerci, Asli Ozmen, Kellie Larsen, Frederick Schatz, Charles J Lockwood, Ozlem Guzeloglu-Kayisli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sefa ArlierDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-0019-8403
Umit A KayisliDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Nihan SemerciDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-4598-8281
Asli OzmenDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Kellie LarsenDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Frederick SchatzDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Charles J LockwoodDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Ozlem Guzeloglu-KayisliDepartment of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
University of South Florida · US

Funding

Progestin Effects on Uterine Hemostatis & AngiogenesisR01HD033937 · NICHD · YALE UNIVERSITY · PI LOCKWOOD, CHARLES JOSEPH · 1995 to 2011
$3.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development RO1 HD 033937NICHD NIH HHS R01 HD033937
6 · The paper itself

Abstract

Progestin-only long-acting reversible-contraceptive (pLARC)-exposed endometria displays decidualized human endometrial stromal cells (HESCs) and hyperdilated thin-walled fragile microvessels. The combination of fragile microvessels and enhanced tissue factor levels in decidualized HESCs generates excess thrombin, which contributes to abnormal uterine bleeding (AUB) by inducing inflammation, aberrant angiogenesis, and proteolysis. The- zinc finger and BTB domain containing 16 (ZBTB16) has been reported as an essential regulator of decidualization. Microarray studies have demonstrated that

Indexed as

Interleukin-8ProgestinsAnimalsCells, CulturedContraceptive AgentsCyclooxygenase 2DeciduaEndometriumEstradiolFemaleGlucocorticoidsGuinea PigsHumansInflammationMedroxyprogesterone AcetatePromyelocytic Leukemia Zinc Finger ProteinContraceptive AgentsCyclooxygenase 2EstradiolGlucocorticoidsInterleukin-8Medroxyprogesterone AcetateProgestinsPromyelocytic Leukemia Zinc Finger ProteinThrombinThromboplastinZBTB16 protein, humanCOX-2decidualizationendometrial stromal cellsIL-8progestin-only contraceptivestissue factorZBTB16

Identifiers

PMID37445713
PMCPMC10341894
OpenAlexW4382138504

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.