Evidence map›Paper›PMID 37445914›Full record

ReviewInternational journal of molecular sciences2023

Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel.

Wei Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Presynaptic Rac1 in the hippocampus selectively regulates working memory.bioRxiv : the preprint server for biology · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wei WangNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0002-3078-1624
Zixu WangNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Jing CaoNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yulan DongNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yaoxing ChenNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.ORCID 0000-0003-2576-5977
China Agricultural University · CN

Funding

Beijing Natural Science Foundation 6222019Chinese National Natural Science Foundation 31873000Chinese National Natural Science Foundation 32172801
6 · The paper itself

Abstract

Animals are required to handle daily massive amounts of information in an ever-changing environment, and the resulting memories and experiences determine their survival and development, which is critical for adaptive evolution. However, intrinsic forgetting, which actively deletes irrelevant information, is equally important for memory acquisition and consolidation. Recently, it has been shown that Rac1 activity plays a key role in intrinsic forgetting, maintaining the balance of the brain's memory management system in a controlled manner. In addition, dysfunctions of Rac1-dependent intrinsic forgetting may contribute to memory deficits in neurological and neurodegenerative diseases. Here, these new findings will provide insights into the neurobiology of memory and forgetting, pathological mechanisms and potential therapies for brain disorders that alter intrinsic forgetting mechanisms.

Indexed as

Brain DiseasesMemoryAnimalsBrainMemory DisordersAlzheimer’s diseaseautistic symptomsintrinsic forgettingRac1

Identifiers

PMID37445914
PMCPMC10341513
OpenAlexW4382403439

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.