Evidence map›Paper›PMID 37445935›Full record

ArticleInternational journal of molecular sciences2023

Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity.

Young Taek Oh, Jun Yang, Christophe Morisseau, Qiyi He, Bruce Hammock, Jang H Youn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Young Taek OhDepartment of Physiology and Neuroscience, University of Southern California Keck School of Medicine, 2250 Alcazar Street, CSC 214, Los Angeles, CA 90089, USA.
Jun YangDepartment of Entomology and Nematology, University of California, Davis, CA 95616, USA.ORCID 0000-0001-8126-1728
Christophe MorisseauDepartment of Entomology and Nematology, University of California, Davis, CA 95616, USA.ORCID 0000-0002-5672-6631
Qiyi HeDepartment of Entomology and Nematology, University of California, Davis, CA 95616, USA.
Bruce HammockDepartment of Entomology and Nematology, University of California, Davis, CA 95616, USA.ORCID 0000-0003-1408-8317
Jang H YounDepartment of Physiology and Neuroscience, University of Southern California Keck School of Medicine, 2250 Alcazar Street, CSC 214, Los Angeles, CA 90089, USA.ORCID 0000-0001-8084-3312
University of California, Davis · USUniversity of Southern California · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Soluble epoxide hydrolase: assessment of in vivo activity and regulation by gut microbiotaR01HL146570 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YOUN, JANG H. · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL146570NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443NIH HHS HL146570NIH HHS P42 ES004699, U54 NS127758, U24 DK097154NIH HHS R35 ES030443-01
6 · The paper itself

Abstract

Oxylipins, oxidation products of unsaturated free fatty acids (FFAs), are involved in various cellular signaling systems. Among these oxylipins, FFA epoxides are associated with beneficial effects in metabolic and cardiovascular health. FFA epoxides are metabolized to diols, which are usually biologically less active, by soluble epoxide hydrolase (sEH). Plasma epoxide-diol ratios have been used as indirect measures of sEH activity. This study was designed to examine the effects of acute elevation of individual plasma FFAs on a variety of oxylipins, particularly epoxides, diols, and their ratios. We tested if FFA epoxide-diol ratios are altered by circulating FFA levels (i.e., substrate availability) independent of sEH activity. Wistar rats received a constant intravenous infusion of olive (70% oleic acid (OA)), safflower seed (72% linoleic acid (LA)), and fish oils (rich in ω-3 FFAs) as emulsions to selectively raise OA, LA, and ω-3 FFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), respectively. As expected, olive, safflower seed, and fish oil infusions selectively raised plasma OA (57%), LA (87%), EPA (70%), and DHA (54%), respectively (

Indexed as

Fatty Acids, NonesterifiedOxylipinsAnimalsDocosahexaenoic AcidsEicosapentaenoic AcidEpoxide HydrolasesEpoxy CompoundsFatty Acids, UnsaturatedFish OilsLinoleic AcidOleic AcidRatsRats, WistarDocosahexaenoic AcidsEicosapentaenoic AcidEpoxide HydrolasesEpoxy CompoundsFatty Acids, NonesterifiedFatty Acids, UnsaturatedFish OilsLinoleic AcidOleic AcidOxylipinsfish oillipid infusionolive oilsafflower seed oilω-3 fatty acids

Identifiers

PMID37445935
PMCPMC10341844
OpenAlexW4382725195

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.