Evidence mapPaperPMID 37445985Full record

ArticleInternational journal of molecular sciences2023

Comparison of Monoamine Oxidase-A, Aβ Plaques, Tau, and Translocator Protein Levels in Postmortem Human Alzheimer's Disease Brain.

Amina U Syed, Christopher Liang, Krystal K Patel, Rommani Mondal, Vallabhi M Kamalia, Taylor R Moran, Shamiha T Ahmed, Jogeshwar Mukherjee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
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  4. Synthesis and Evaluation of Radioiodinated [Journal of labelled compounds & radiopharmaceuticals · 2026
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  5. Reduction in [Brain research · 2025
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  6. [Biomolecules · 2025
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  7. Article
  8. Article
  9. Article
  10. Article
  11. [International journal of molecular sciences · 2024
    Article
  12. Article
  13. [Neurology international · 2024
    Article
  14. Article
  15. Article
  16. [Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amina U SyedPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Krystal K PatelPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Rommani MondalPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Vallabhi M KamaliaPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Taylor R MoranPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Shamiha T AhmedPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-1009-877X
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · 1994 to 2025
$19.5M
NCI NIH HHS P30 CA062203NIH HHS AG 079189 and AG 029479
6 · The paper itself

Abstract

Increased monoamine oxidase-A (MAO-A) activity in Alzheimer's disease (AD) may be detrimental to the point of neurodegeneration. To assess MAO-A activity in AD, we compared four biomarkers, Aβ plaques, tau, translocator protein (TSPO), and MAO-A in postmortem AD. Radiotracers were [

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainHumansIodine RadioisotopesMonoamine OxidasePositron-Emission TomographyReceptors, GABAtau ProteinsAmyloid beta-PeptidesIodine-125Iodine RadioisotopesMonoamine OxidaseReceptors, GABAtau ProteinsTSPO protein, human[125I]IPPI[18]FAZIN3[18F]FEPPA[18F]flotazaAlzheimer’s diseaseAβ plaqueshuman taumonoamine oxidase-A

Identifiers

PMID37445985
PMCPMC10341404
OpenAlexW4382725845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.