Evidence map›Paper›PMID 37446049›Full record

ArticleInternational journal of molecular sciences2023

Transcriptome Changes of Hematopoietic Stem and Progenitor Cells in the Peripheral Blood of COVID-19 Patients by scRNA-seq.

Jinfu Zhang, Xin Shu, Rong Deng, Zihao Yang, Manling Shu, Xiangying Ou, Xuan Zhang, Zhenyu Wu, Huihong Zeng, Lijian Shao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jinfu ZhangDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.ORCID 0000-0001-8004-4887
Xin ShuDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Rong DengDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Zihao YangDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Manling ShuDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.ORCID 0000-0002-2714-7892
Xiangying OuDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Xuan ZhangDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Zhenyu WuDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Huihong ZengDepartment of Histology and Embryology, School of Basic Medicine, Nanchang University, Nanchang 330006, China.
Lijian ShaoDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, China.
Nanchang University · CN

Funding

Graduate Innovation Special Fund of Jiangxi Province YC2021-S066Interdisciplinary Innovation Fund of Natural Science in Nanchang University 9166-27060003-YB13Jiangxi Provincial Natural Science Foundation 20192BBG70043Jiangxi Provincial Natural Science Foundation 20202ACB206009National Natural Science Foundation of China 81960104National Natural Science Foundation of China 82073484National Natural Science Foundation of China 82260117
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) threatens public health all over the world. It is well-accepted that the immune cells in peripheral blood are widely involved in the pathological process of COVID-19. However, hematopoietic stem and progenitor cells (HSPCs), as the main source of peripheral immune cells, have not been well studied during COVID-19 infection. We comprehensively revealed the transcriptome changes of peripheral blood HSPCs after COVID-19 infection and vaccination by single-cell RNA-seq. Compared with healthy individuals, the proportion of HSPCs in COVID-19 patients significantly increased. The increase in the proportion of HSPCs might be partly attributed to the enhancement of the HSPCs proliferation upon COVID-19 infection. However, the stemness damage of HSPCs is reflected by the decrease of differentiation signal, which can be used as a potential specific indicator of the severity and duration of COVID-19 infection. Type I interferon (IFN-I) and translation signals in HSPCs were mostly activated and inhibited after COVID-19 infection, respectively. In addition, the response of COVID-19 vaccination to the body is mild, while the secondary vaccination strengthens the immune response of primary vaccination. In conclusion, our study provides new insights into understanding the immune mechanism of COVID-19 infection.

Indexed as

COVID-19TranscriptomeCOVID-19 VaccinesHematopoietic Stem CellsHumansSingle-Cell Gene Expression AnalysisCOVID-19 VaccinesCOVID-19COVID-19 vaccinationhematopoietic stem and progenitor cells (HSPCs)immune responsesingle-cell RNA sequencing (scRNA-seq)

Identifiers

PMID37446049
PMCPMC10341542
OpenAlexW4382791901

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.