ArticleInternational journal of molecular sciences2023
Cryopreservation Induces Acetylation of Metabolism-Related Proteins in Boar Sperm.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- LDHC Hyperacetylation Disrupts the Guanidinoacetic Acid-Creatine Axis Underlying Cryoinjury in Boar Sperm: Rescue by GAA Supplementation.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of Sodium Butyrate on Sperm Function and Protein Acetylation in Fresh and Frozen-Thawed Boar Spermatozoa.Animals : an open access journal from MDPI · 2026Article
- Perspectives in porcine semen conservation (liquid and frozen).The Journal of reproduction and development · 2026Review
- Comparative Analysis of Classic Semen Extenders for Frozen-Thawed Boar Semen.Animals : an open access journal from MDPI · 2025Article
- Proteomic analysis reveals the difference between the spermatozoa of young and old Sus scrofa.Scientific reports · 2025Article
- Seminal plasma microbiomes, sperm parameters, and cryopreservation in a healthy fertile population.Frontiers in microbiology · 2024Article
- A review on the functional roles of trehalose during cryopreservation of small ruminant semen.Frontiers in veterinary science · 2024Review
- Semen quality and frozen semen production in Pasundan bulls: A molecular weight perspective on seminal plasma and spermatozoa protein.Journal of advanced veterinary and animal research · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Cryodamage affects the normal physiological functions and survivability of boar sperm during cryopreservation. Lysine acetylation is thought to be an important regulatory mechanism in sperm functions. However, little is known about protein acetylation and its effects on cryotolerance or cryodamage in boar sperm. In this study, the characterization and protein acetylation dynamics of boar sperm during cryopreservation were determined using liquid chromatography-mass spectrometry (LC-MS). A total of 1440 proteins were identified out of 4705 modified proteins, and 2764 quantifiable sites were elucidated. Among the differentially modified sites, 1252 were found to be upregulated compared to 172 downregulated sites in fresh and frozen sperms. Gene ontology indicated that these differentially modified proteins are involved in metabolic processes and catalytic and antioxidant activities, which are involved in pyruvate metabolism, phosphorylation and lysine degradation. In addition, the present study demonstrated that the mRNA and protein expressions of SIRT5, IDH2, MDH2 and LDHC, associated with sperm quality parameters, are downregulated after cryopreservation. In conclusion, cryopreservation induces the acetylation and deacetylation of energy metabolism-related proteins, which may contribute to the post-thawed boar sperm quality parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.