Evidence map›Paper›PMID 37446252›Full record

ArticleInternational journal of molecular sciences2023

The Role of Hyperthermia in Potentiation of Anti-Angiogenic Effect of Cisplatin and Resveratrol in Mice Bearing Solid Form of Ehrlich Ascites Tumour.

Darko Kučan, Nada Oršolić, Dyana Odeh, Snježana Ramić, Boris Jakopović, Jelena Knežević, Maja Jazvinšćak Jembrek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Molecular Mechanisms of Mangiferin on Neuroinflammation for Treating Major Depressive Disorder Based on Network Pharmacology and Bioinformatics Analysis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  3. Review
  4. Review
  5. Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Darko KučanDivision of Abdominal Surgery and Organ Transplantation, Department of Surgery, University Hospital Merkur, Zajčeva 19, 10000 Zagreb, Croatia.ORCID 0000-0001-9259-3103
Nada OršolićDivision of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia.ORCID 0000-0001-5102-3606
Dyana OdehDivision of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia.ORCID 0000-0002-6182-755X
Snježana RamićDepartment of Pathology, University Cancer Hospital, Sestre Milosrdnice University Hospital Centre, Ilica 197, 10000 Zagreb, Croatia.ORCID 0000-0002-5916-8815
Boris JakopovićDr Myko San-Health from Mushrooms Co., Miramarska Cesta 109, 10000 Zagreb, Croatia.
Jelena KneževićDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0002-3152-3563
Maja Jazvinšćak JembrekDivision of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.ORCID 0000-0002-5037-3919
University of Zagreb · HRCatholic University of Croatia · HRKlinička bolnica Merkur · HRRuđer Bošković Institute · HRUniversity Hospital Centre Zagreb · HR

Funding

University of Zagreb 20286437
6 · The paper itself

Abstract

The aim of this study was to investigate the therapeutic potential of resveratrol in combination with cisplatin on the inhibition of tumour angiogenesis, growth, and macrophage polarization in mice bearing the solid form of an Ehrlich ascites tumour (EAT) that were exposed to whole-body hyperthermia treatment. In addition, we investigated whether a multimodal approach with hyperthermia and resveratrol could abolish cisplatin resistance in tumour cells through the modulation of histone deacetylase (HDAC) activity and levels of heat shock proteins (HSP70/HSP90) and contribute to the direct toxicity of cisplatin on tumour cells. The tumour was induced by injecting 1 × 10

Indexed as

Carcinoma, Ehrlich TumorHyperthermia, InducedAngiogenesis InhibitorsAnimalsCisplatinMiceResveratrolAngiogenesis InhibitorsCisplatinResveratrolangiogenesiscisplatinEhrlich solid tumourHSP70/HSP90miceresveratrolwhole body hyperthermia treatment

Identifiers

PMID37446252
PMCPMC10341868
OpenAlexW4383227325

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.