Evidence map›Paper›PMID 37447263›Full record

ArticleNutrients2023

Association between Gut Microbiota and Digestive System Cancers: A Bidirectional Two-Sample Mendelian Randomization Study.

Ning Xie, Ziwei Wang, Qiuai Shu, Xiru Liang, Jinhai Wang, Kaichun Wu, Yongzhan Nie, Yongquan Shi, Daiming Fan, Jian Wu

Abstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ning XieDepartment of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710049, China.
Ziwei WangDepartment of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710049, China.
Qiuai ShuDepartment of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710049, China.
Xiru LiangDepartment of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710049, China.
Jinhai WangDepartment of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710049, China.
Kaichun WuNational Clinical Research Center for Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an 710032, China.
Yongzhan NieNational Clinical Research Center for Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an 710032, China.
Yongquan ShiNational Clinical Research Center for Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an 710032, China.
Daiming FanNational Clinical Research Center for Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an 710032, China.ORCID 0000-0002-2466-5002
Jian WuNational Clinical Research Center for Digestive Diseases, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an 710032, China.

Funding

The study was supported by grants from the National Key Technology R&D Program of China No. 2015BAI13B07
6 · The paper itself

Abstract

Accumulating evidence indicates that gut microbiota closely correlates with the tumorigenesis of digestive system cancers (DSCs). However, whether the causality between gut microbiota and DSCs exists is unknown. Genome-wide association study (GWAS) summary statistics for gut microbiota and DSCs and the bidirectional two-sample Mendelian randomization (MR) analysis were utilized to assess the causality between gut microbiota and DSCs. Sensitivity analyses were performed to evaluate the robustness of our results. We found that the

Indexed as

Digestive System NeoplasmsGastrointestinal MicrobiomeLiver NeoplasmsGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single Nucleotidecausalitydigestive system cancersgut microbiotaMendelian randomization

Identifiers

PMID37447263
PMCPMC10343867

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.