ArticleNutrients2023
Negative Association between Serum Vitamin D Levels and Depression in a Young Adult US Population: A Cross-Sectional Study of NHANES 2007-2018.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Association between serum vitamin D levels and polycystic ovary syndrome: a cross-sectional study.Frontiers in nutrition · 2026Article
- Association between serum 25-hydroxyvitamin D concentrations and overactive bladder in female: a mediation analysis of inflammatory biomarkers.Frontiers in nutrition · 2026Article
- Article
- Association of vitamin D with depression and anxiety in polycystic ovary syndrome in Saudi Arabia.Journal of family medicine and primary care · 2025Article
- Associations of dietary and plasma lutein + zeaxanthin with depression in US adults: findings from NHANES.Asia Pacific journal of clinical nutrition · 2025Article
- Preventive and therapeutic effect of vitamin D on depression-like behavior in a mouse adolescent depression model and its association with BDNF protein expression.Frontiers in psychiatry · 2024Article
- Association of serum vitamin D with anxiety in US adults: a cross-sectional study.Frontiers in nutrition · 2024Article
- Increased fruit intake is associated with reduced risk of depression: evidence from cross-sectional and Mendelian randomization analyses.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVitamin D has been suggested to play a role in the development of depression, but the nature of the relationship between the two is still not fully understood. Although some studies have shown an association between vitamin D deficiency and depression, others have yielded inconsistent or inconclusive results. As a result, further research is needed to better understand the relationship between vitamin D and depression.
objectivesThis study aims to assess the association between serum vitamin D and the risk of depressive symptoms in individuals aged 20 years and older in the United States.
methodsWe selected 7562 participants from the 2007-2018 US National Health and Nutrition Examination Survey (NHANES). Participants' serum vitamin D levels were determined from laboratory data, and those with a Patient Health Questionnaire-9 (PHQ-9) score of ≥ 10 were considered to have depressive symptoms. Associations between vitamin D and depressive symptoms were investigated using multiple logistic regression, subgroup analysis, and smoothed curve fitting.
resultsIn our study, 11.17% of the participants had depression. Multiple regression stratified analysis showed a significant inverse association between serum vitamin D and depression in the 29-39 years age group after full adjustment (OR = 0.54, 95% CI: 0.31-0.95,
conclusionsThe association between serum vitamin D and depressive status in US adults varied across populations. Among those aged 29-39 years, vitamin D supplementation tended to show a lower rate of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.