ArticleCancer cell2023
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling.
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Article in Cancer cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 71 citations in OpenAlex.
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- Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026Review
- Radiotherapy resistance in glioblastoma: Mechanistic insights and novel therapeutic approaches (Review).International journal of oncology · 2026Review
- Time-staggered chemo-immunotherapy via engineered nanofiber resists postoperative dynamic immunosuppression in glioblastoma.Nature communications · 2026Article
- Article
- Human cerebral organoids with microglia and vasculature model glioma stem cell interactions and radiotherapy response.Cell reports methods · 2026Article
- Extracellular vesicles from chemotherapy-induced senescent tumor cells reprogram hepatic phospholipid metabolism to promote pancreatic cancer liver metastasis.Journal of experimental & clinical cancer research : CR · 2026Article
- LILRB3 inhibition reverses immunosuppression in glioma: a nanoparticle-based therapeutic strategy.Journal of nanobiotechnology · 2026Article
- Exploring the dual role of extracellular vesicles in coagulation and immune modulation in glioblastoma.Scientific reports · 2026Article
- Senescent cell clearance suppresses post-radiotherapy glioblastoma recurrence via the IL-6/JAK2/STAT3 pathway.Molecular and cellular biochemistry · 2026Article
- Glutamine metabolism and its roles in tumor radiotherapy by regulating DNA damage repair.Frontiers in cell and developmental biology · 2026Review
- Emerging roles of haemostatic proteins as markers of disease progression and prognosis in breast cancer.Exploration of targeted anti-tumor therapy · 2026Review
- The dynamic myeloid-enriched microenvironment of glioblastoma: a major challenge to immunotherapy efficacy.Frontiers in immunology · 2026Review
- Decoding the tumor-aging axis: from bench to clinical.Frontiers in immunology · 2026Review
- Network-Based Prediction of Oligodendroglioma Driver Gene Candidates within the Region of the 1p/19q Co-deletion Utilizing Single-Cell Transcriptomes.Computational and structural biotechnology journal · 2026Article
- The Implications of Radiotherapy-Induced Cellular Senescence for Cancer Treatment and Tumor Microenvironment Modulation.International journal of biological sciences · 2026Review
- Extracellular vesicles derived from irradiated tumor cells foster immunosuppressive macrophages formation to promote esophageal squamous cell carcinoma immune evasion.International journal of biological sciences · 2026Article
- Dual-targeted bacterial outer membrane vesicles enhance glioblastoma immunotherapy by regulating tumor microenvironment and inducing IFN-γ-mediated ferroptosis.Journal of nanobiotechnology · 2025Article
- Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype.CNS oncology · 2025Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 8 institutions in 2 countries.
Hye-Min JeonDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Jeong-Yub KimDivisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Hee Jin ChoDepartment of Biomedical Convergence Science and Technology, Kyungpook National University, Daegu, Korea.
Won Jun LeeDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Dayna NguyenDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Sung Soo KimDepartment of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Young Taek OhDepartment of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Hee-Jin KimDivisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Chan-Woong JungDivisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Gonzalo PineroIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Tanvi JoshiIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Dolores HambardzumyanIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Takuya SakaguchiDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Christopher G HubertDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Thomas M McIntyreDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Howard A FineDepartment of Neurology, Weill Cornell Medicine, New York, NY, USA.
Candece L GladsonDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Bingcheng WangDepartment of Medicine, MetroHealth Campus, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Benjamin W PurowDepartment of Neurology, UVA Cancer Center, University of Virginia Health System, Charlottesville, VA, USA.
Jong Bae ParkDepartment of System Cancer Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Myung Jin ParkDivisions of Radiation Cancer Research, Research Center for Radio-Senescence, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Do-Hyun NamInstitute for Refractory Cancer Research, Samsung Medical Center, Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Department of Neurosurgery Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jeongwu LeeDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: leej7@ccf.org.
Cleveland Clinic Lerner College of Medicine · USKorea Institute of Radiological and Medical Sciences · KRIcahn School of Medicine at Mount Sinai · USNational Cancer Center · KRCornell University · USKyungpook National University · KRMetroHealth Medical Center · USUniversity of Virginia Health System · US
Funding
(PQ1) HIV-infected T-cell exosomes in lung cancer progressionR01CA250067 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JIN, GE, WANG, BINGCHENG · 2020 to 2024
$3.7MTargeting EphA2 in GlioblastomaR01NS096956 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI WANG, BINGCHENG · 2016 to 2021
$2.6MTargeting oncogenic dopamine receptor signaling in glioblastomaR01CA223370 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LEE, JEONGWU · 2019 to 2023
$2.4MHypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexesR01HL158669 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MCINTYRE, THOMAS M · 2021 to 2024
$2.3MEndocytic Trafficking of ADCs in GBM cancer stem-like cellsR01NS111981 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI CATHLEEN R CARLIN, Candece L Gladson · 2019 to 2026
$2.3MPolycomb and Cellular Hierarchy in the BrainR01NS082312 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI LEE, JEONGWU · 2013 to 2017
$1.7MNCI NIH HHS R01 CA223370NCI NIH HHS R01 CA250067NHLBI NIH HHS R01 HL158669NINDS NIH HHS R01 NS082312NINDS NIH HHS R01 NS096956NINDS NIH HHS R01 NS111981
Abstract
Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance and recurrence. Through a cell surface marker screen, we identified that CD142 (tissue factor or F3) is robustly induced in the senescence-associated β-galactosidase (SA-βGal)-positive GBM cells after irradiation. F3 promotes clonal expansion of irradiated SA-βGal
Indexed as
Brain NeoplasmsGlioblastomaCell Line, TumorHumansNeoplasm Recurrence, LocalSignal TransductionThromboplastinTumor MicroenvironmentThromboplastinglioblastomasenescencetherapeutic resistancetissue factortumor microenvironment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.