Evidence map›Paper›PMID 37452403›Full record

ArticleBMC nutrition2023

Short-term effect of plant-based Nordic diet versus carbohydrate-restricted diet on glucose levels in gestational diabetes - the eMOM pilot study.

Lisa Torsdatter Markussen, Jemina Kivelä, Jaana Lindström, Reza A Ashrafi, Seppo Heinonen, Saila Koivusalo, Jelena Meinilä

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03681054 (Effects of Guided Dietary Patterns on Metabolic Outcomes in Overweight Pregnant Women With Gestational Diabetes and on Offspring Body Composition), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03681054 naactive not recruitingnot on this map

Effects of Guided Dietary Patterns on Metabolic Outcomes in Overweight Pregnant Women With Gestational Diabetes and on Offspring Body Composition

TypeinterventionalSponsorHelsinki University Central HospitalRan2018 to 2027Enrolled42ConditionsDiabetes, Gestational, Dietary Modification, Glucose Intolerance During Pregnancy, Body CompositionArmsCarbohydrate restricted diet, Plant-protein based diet
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lisa Torsdatter MarkussenDepartment of Food and Nutrition, University of Helsinki, Helsinki, Finland. lisa.markussen@hus.fi.ORCID https://orcid.org/0000-0002-9337-1198
Jemina KiveläPopulation Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Jaana LindströmPopulation Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Reza A AshrafiDepartment of Computer Science, Aalto University, Helsinki, Finland.
Seppo HeinonenDepartment of Obstetrics and Gynecology, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Saila Koivusalo *Department of Obstetrics and Gynecology, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Jelena Meinilä *Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
Helsinki University Hospital · FIUniversity of Helsinki · FIAalto University · FIFinnish Institute for Health and Welfare · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal nutritional treatment for gestational diabetes (GDM) is still a matter of debate. With increasing rates of GDM and potential negative consequences for the health of mother and child, the best treatment should be established. The Nordic diet with emphasis on plant-based protein show promising health outcomes in other populations but has yet to be investigated in GDM population. The aim of this study, which is part of the "Effect of plant-based Nordic diet versus carbohydrate-restricted diet on glucose levels in gestational diabetes" (eMOM) pilot study was to compare the short-term effects of healthy Nordic diet (HND) and the currently recommended moderate restriction of carbohydrates diet (MCRD) on glucose and lipid metabolism in women with GDM.

methodsThis was a randomized crossover where each of the diet interventions (HND and MCRD) were consumed for 3 days with a 3-day wash-out period in between. In total, 42 pregnant women diagnosed with GDM (< 29 + 0 gestational week) were randomized. Glucose data was collected by continuous glucose monitors (CGM, Freestyle Libre®, Abbott, USA) worn for 14 days, and participants gave blood samples before and after diet interventions. The primary outcome was time spent in glucose target range (TIR, < 7.8 mmol/L). TIR, 3-day mean tissue glucose as well as changes in fasting glucose, homeostatic model of insulin resistance (HOMA-IR) and blood lipids were analyzed with paired samples statistical analyses.

resultsThirty-six women with complete 14 days CGM data were analyzed. Both diet interventions produced a high degree of TIR (99% SD 1.8), without a difference between the diets (p = 0.727). The 3-day mean glucose was significantly lower in HND than in MCRD (p = 0,049). Fasting insulin (p = 0,034), insulin resistance (p = 0,030), total and LDL cholesterol (p = 0,023 and 0,008) reduced more in the MCRD diet than the HND. NS differences in any other measure of CGM or blood tests.

conclusionsHND and MCRD did not differ in terms of their short-term effect on TIR. A larger study with sufficient power is needed to confirm the differences in short-term mean glucose, insulin resistance and lipid metabolism.

trial registrationRegistered in clinicaltrials.gov (21/09/2018, NCT03681054).

Indexed as

Carbohydrate restrictionCGMCrossoverGestational Diabetes MellitusGlycemic controlMedical nutrition therapyNordic Diet

Identifiers

PMID37452403
PMCPMC10349459
OpenAlexW4384298194

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.