Evidence map›Paper›PMID 37455299›Full record

ArticleScientific reports2023

Photoinduced bidirectional switching in lipid membranes containing azobenzene glycolipids.

Jonas E Warias, Franziska Reise, Svenja C Hövelmann, Rajendra P Giri, Michael Röhrl, Jule Kuhn, Malte Jacobsen, Kuntal Chatterjee, Thomas Arnold, Chen Shen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Jonas E WariasInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Franziska ReiseOtto Diels Institute of Organic Chemistry, Kiel University, Otto-Hahn-Platz 3-4, 24118, Kiel, Germany.
Svenja C HövelmannInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Rajendra P GiriInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Michael RöhrlOtto Diels Institute of Organic Chemistry, Kiel University, Otto-Hahn-Platz 3-4, 24118, Kiel, Germany.
Jule KuhnInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Malte JacobsenInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Kuntal ChatterjeeInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Thomas ArnoldDiamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 ODE, UK.
Chen ShenDeutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607, Hamburg, Germany.
Sven FestersenInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Andrea SartoriInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Philipp JordtInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Olaf M MagnussenInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany.
Thisbe K LindhorstOtto Diels Institute of Organic Chemistry, Kiel University, Otto-Hahn-Platz 3-4, 24118, Kiel, Germany.
Bridget M MurphyInstitute of Experimental and Applied Physics, Kiel University, Leibnizstr. 19, 24118, Kiel, Germany. murphy@physik.uni-kiel.de.
Kiel University · DEDeutsches Elektronen-Synchrotron DESY · DEEuropean Synchrotron Radiation Facility · FRRutherford Appleton Laboratory · GB

Funding

Bundesministerium für Bildung und Forschung 05K19FK2Deutsche Forschungsgemeinschaft SFB677Deutsches Elektronen-Synchrotron CMWS - Startup grant
6 · The paper itself

Abstract

Following the reaction of biological membranes to external stimuli reveals fundamental insights into cellular function. Here, self-assembled lipid monolayers act as model membranes containing photoswitchable azobenzene glycolipids for investigating structural response during isomerization by combining Langmuir isotherms with X-ray scattering. Controlled in-situ trans/cis photoswitching of the azobenzene N = N double bond alters the DPPC monolayer structure, causing reproducible changes in surface pressure and layer thickness, indicating monolayer reorientation. Interestingly, for monolayers containing azobenzene glycolipids, along with the expected DPPC phase transitions an additional discontinuity is observed. The associated reorintation represents a crossover point, with the surface pressure and layer thickness changing in opposite directions above and below. This is evidence that the azobenzene glycolipids themselves change orientation within the monolayer. Such behaviour suggests that azobenzene glycolipids can act as a bidirectional switch in DPPC monolayers providing a tool to investigate membrane structure-function relationships in depth.

Identifiers

PMID37455299
PMCPMC10350456
OpenAlexW4384455439

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.