SynthesisJournal of Parkinson's disease2023
Motor Memory Consolidation Deficits in Parkinson's Disease: A Systematic Review with Meta-Analysis.
Synthesis in Journal of Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- No effect of anodal high-definition transcranial direct current stimulation during motor sequence learning in older people.GeroScience · 2026Trial
- Review
- Cardiovascular exercise enhances motor learning across multiple sessions in people with Parkinson's disease: a randomized controlled pilot trial.NPJ science of learning · 2025Article
- The impact of loneliness on balance learning ability in aging patients with Parkinson's disease.BMC geriatrics · 2025Article
- Sensory profiles in older adults with orthopedic conditions during quiet stance: a cross-sectional study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Sensorimotor Network Segregation Predicts Long-Term Learning of Writing Skills in Parkinson's Disease.Brain sciences · 2024Article
- Sleep improves accuracy, but not speed, of generalized motor learning in young and older adults and in individuals with Parkinson's disease.Frontiers in behavioral neuroscience · 2024Article
- Specialized Allied Health Care for Parkinson's Disease: State of the Art and Future Directions.Journal of Parkinson's disease · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe ability to encode and consolidate motor memories is essential for persons with Parkinson's disease (PD), who usually experience a progressive loss of motor function. Deficits in memory encoding, usually expressed as poorer rates of skill improvement during motor practice, have been reported in these patients. Whether motor memory consolidation (i.e., motor skill retention) is also impaired is unknown.
objectiveTo determine whether motor memory consolidation is impaired in PD compared to neurologically intact individuals.
methodsWe conducted a pre-registered systematic review (PROSPERO: CRD42020222433) following PRISMA guidelines that included 46 studies.
resultsMeta-analyses revealed that persons with PD have deficits in retaining motor skills (SMD = -0.17; 95% CI = -0.32, -0.02; p = 0.0225). However, these deficits are task-specific, affecting sensory motor (SMD = -0.31; 95% CI -0.47, -0.15; p = 0.0002) and visuomotor adaptation (SMD = -1.55; 95% CI = -2.32, -0.79; p = 0.0001) tasks, but not sequential fine motor (SMD = 0.17; 95% CI = -0.05, 0.39; p = 0.1292) and gross motor tasks (SMD = 0.04; 95% CI = -0.25, 0.33; p = 0.7771). Importantly, deficits became non-significant when augmented feedback during practice was provided, and additional motor practice sessions reduced deficits in sensory motor tasks. Meta-regression analyses confirmed that deficits were independent of performance during encoding, as well as disease duration and severity.
conclusionOur results align with the neurodegenerative models of PD progression and motor learning frameworks and emphasize the importance of developing targeted interventions to enhance motor memory consolidation in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.