Evidence map›Paper›PMID 37458426›Full record

ArticleJournal of visualized experiments : JoVE2023

Alignment of Visible-Light Optical Coherence Tomography Fibergrams with Confocal Images of the Same Mouse Retina.

Shichu Chang, Wenjin Xu, Weijia Fan, John A McDaniel, Marta Grannonico, David A Miller, Mingna Liu, Hao F Zhang, Xiaorong Liu

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shichu ChangDepartment of Biology, University of Virginia.
Wenjin XuDepartment of Biology, University of Virginia.
Weijia FanDepartment of Biomedical Engineering, Northwestern University.
John A McDanielDepartment of Biology, University of Virginia.
Marta GrannonicoDepartment of Biology, University of Virginia.
David A MillerDepartment of Biomedical Engineering, Northwestern University.
Mingna LiuDepartment of Biology, University of Virginia.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University.
Xiaorong LiuDepartment of Biology, University of Virginia; Department of Ophthalmology, University of Virginia; Program in Fundamental Neuroscience, University of Virginia; Department of Psychology, University of Virginia; xl8n@virginia.edu.
University of Virginia · US

Funding

Modulating aqueous humor outflow with engineered nanoparticles for glaucomaR01EY035088 · NEI · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · PI Xiaorong Liu, Hu Yang · 2023 to 2026
$2.0M
Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0M
NEI NIH HHS R01 EY029121NEI NIH HHS R01 EY035088
6 · The paper itself

Abstract

In recent years, in vivo retinal imaging, which provides non-invasive, real-time, and longitudinal information about biological systems and processes, has been increasingly applied to obtain an objective assessment of neural damage in eye diseases. Ex vivo confocal imaging of the same retina is often necessary to validate the in vivo findings especially in animal research. In this study, we demonstrated a method for aligning an ex vivo confocal image of the mouse retina with its in vivo images. A new clinical-ready imaging technology called visible light optical coherence tomography fibergraphy (vis-OCTF) was applied to acquire in vivo images of the mouse retina. We then performed the confocal imaging of the same retina as the "gold standard" to validate the in vivo vis-OCTF images. This study not only enables further investigation of the molecular and cellular mechanisms but also establishes a foundation for a sensitive and objective evaluation of neural damage in vivo.

Indexed as

RetinaTomography, Optical CoherenceAnimalsLightMice

Identifiers

PMID37458426
PMCPMC11932515
OpenAlexW4382646270

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.