Evidence map›Paper›PMID 37458936›Full record

ReviewStem cell reviews and reports2023

Stem Cells and Exosome Applications for Cutaneous Wound Healing: From Ground to Microgravity Environment.

Wenya Zhang, Jinhua Zhang, Yan Cui, Yongxiang Zhao, Xiaohua Lei

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Wenya Zhang *Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University, Nanning, 530021, China.
Jinhua Zhang *Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University, Nanning, 530021, China.
Yan CuiDepartment of General Surgery, Strategic Support Force Medical Center, Chaoyang District, Beijing, 100101, China.
Yongxiang ZhaoGuangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, National Center for International Research of Bio-targeting Theranostics, Guangxi Medical University, Nanning, 530021, China. yongxiang_zhao@126.com.
Xiaohua LeiCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. xh.lei@siat.ac.cn.ORCID 0000-0001-8095-9008
Guangxi Medical University · CNBeijing Chaoyang Emergency Medical Center · CNChinese Academy of Sciences · CN

Funding

Guangxi science and technology bases and talent special project AD17129062Guangxi Talent Highland of Preservation and Deep Processing Research in Fruit and Vegetables AB20117001National Key Research and Development Program of China 2021YFA0719303National Natural Science Foundation of China 32271284Open Project Fund of the Logistics Research Program ZZBWS21J2001
6 · The paper itself

Abstract

The increasing number of astronauts entering microgravity environments for long-term space missions has resulted in serious health problems, including accidental injury and trauma. Skin, as the largest organ and outermost layer of the human body, has the ability to self-renew and withstand a variety of harmful biological and environmental influences. Recent spaceflight experiments and simulated studies have begun to concern the effects of microgravity on the growth of skin cells and the process of cutaneous wound healing. However, the mechanisms of the adverse effects of microgravity on skin cells and potential intervention measures are still limited. Stem cells and their exosomes provide unique opportunities for the cutaneous wound healing as they have been used to improve skin repair. This review discusses the effects of microgravity on wound healing, from cell morphological changes to molecular level alterations. Furthermore, the current research on wound healing treatment utilizing stem cells and their exosomes on the ground is summarized. Finally, this review proposes promising therapeutic strategies using stem cells or exosomes for wound healing in the microgravity environment. Graphical Abstract.

Indexed as

ExosomesSkinStem CellsStem Cell TransplantationWeightlessnessWound HealingAnimalsHumansExosomesMicrogravityStem cellsWound healing

Identifiers

PMID37458936
OpenAlexW4384560086

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.