Evidence map›Paper›PMID 37461525›Full record

ArticlebioRxiv : the preprint server for biology2023

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.

S S Madhavan, S Roa Diaz, S Peralta, M Nomura, C D King, A Lin, D Bhaumik, S Shah, T Blade, W Gray and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

S S MadhavanBuck Institute for Research on Aging, Novato, CA, USA.
S Roa DiazBuck Institute for Research on Aging, Novato, CA, USA.
S PeraltaBuck Institute for Research on Aging, Novato, CA, USA.
M NomuraBuck Institute for Research on Aging, Novato, CA, USA.
C D KingBuck Institute for Research on Aging, Novato, CA, USA.
A LinBuck Institute for Research on Aging, Novato, CA, USA.
D BhaumikBuck Institute for Research on Aging, Novato, CA, USA.
S ShahBuck Institute for Research on Aging, Novato, CA, USA.
T BladeBuck Institute for Research on Aging, Novato, CA, USA.
W GrayBuck Institute for Research on Aging, Novato, CA, USA.
M ChamoliBuck Institute for Research on Aging, Novato, CA, USA.
B EapBuck Institute for Research on Aging, Novato, CA, USA.
O PandaBuck Institute for Research on Aging, Novato, CA, USA.
D DiazBuck Institute for Research on Aging, Novato, CA, USA.
T Y GarciaBuck Institute for Research on Aging, Novato, CA, USA.
B J StubbsBuck Institute for Research on Aging, Novato, CA, USA.
G J LithgowBuck Institute for Research on Aging, Novato, CA, USA.
B SchillingBuck Institute for Research on Aging, Novato, CA, USA.
E VerdinBuck Institute for Research on Aging, Novato, CA, USA.
A R ChaudhuriBuck Institute for Research on Aging, Novato, CA, USA.
J C NewmanBuck Institute for Research on Aging, Novato, CA, USA.
Buck Institute for Research on Aging · USUniversity of Southern California · US

Funding

Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
Mechanisms of the signaling metabolite β-hydroxybutyrate in Alzheimer's disease and the aging brainR01AG067333 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI John C Newman · 2020 to 2026
$4.8M
NIA NIH HHS R01 AG067333NIA NIH HHS T32 AG000266NIA NIH HHS T32 AG052374
6 · The paper itself

Abstract

Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). Here, we identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility in the aging brain. βHB is a small molecule metabolite which primarily provides an oxidative substrate for ATP during hypoglycemic conditions, and also regulates other cellular processes through covalent and noncovalent protein interactions. We demonstrate βHB-induced protein insolubility across

Identifiers

PMID37461525
PMCPMC10349929
OpenAlexW4382986778

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.