Evidence map›Paper›PMID 37461719›Full record

ArticleResearch square2023

Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.

Marisol Herrera-Rivero, Karina Gutiérrez-Fragoso, Anbupalam Thalamuthu, Azmeraw T Amare, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry and 113 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

123 authors at 20 institutions in 15 countries.

Marisol Herrera-RiveroUniversity of Münster.ORCID 0000-0001-7064-9487
Karina Gutiérrez-Fragoso
Anbupalam ThalamuthuUniversity of New South Wales.
Azmeraw T AmareUniversity of Adelaide, AUSTRALIA.ORCID 0000-0002-7940-0335
Mazda Adli
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University.
Nirmala AkulaNational Institutes of Health, US Dept of Health & Human Services.
Raffaella ArdauHospital University Agency of Cagliari.
Bárbara AriasFacultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM.ORCID 0000-0001-9181-2132
Jean-Michel AubryGeneva University Hospitals.
Lena Backlund
Frank Bellivier
Antonio Benabarre
Susanne Bengesser
Bhattacharjee Abesh
Joanna BiernackaMayo Clinic.ORCID 0000-0001-9350-4440
Armin Birner
Pablo CervantesMcGill University Health Centre.
Hsi-Chung ChenNational Taiwan University Hospital.ORCID 0000-0003-3191-0093
Caterina Chillotti
Sven CichonMayo Clinic.
Scott ClarkUniversity of Adelaide.ORCID 0000-0003-1640-5611
Francesc Colom
Cristiana CruceanuMax Plank Institute for Psychiatry.ORCID 0000-0002-7799-5531
Piotr CzerskiPoznan University of Medical Sciences.ORCID 0000-0003-0745-5916
Nina Dalkner
Franziska DegenhardtUniversity of Bonn.
Maria Del ZompoUniversity of Cagliari.ORCID 0000-0001-9491-5938
J Raymond DePauloJohns Hopkins University.ORCID 0000-0001-9221-9226
Bruno Etain
Peter FalkaiUniversity Hospital LMU.
Ewa Ferensztajn-Rochowiak
Andreas J ForstnerUniversity of Bonn, School of Medicine & University Hospital Bonn.ORCID 0000-0002-1876-6368
Josef FrankCentral Institute for Mental Health.ORCID 0000-0003-4867-9465
Louise FrisenSchool of Medicine & University Hospital Bonn.
Mark FryeMayo Clinic.ORCID 0000-0001-6997-4215
Janice FullertonNeuroscience Research Australia.ORCID 0000-0003-4014-4490
Carla Gallo
Sebastien Gard
Fernando Goes
Maria Grigoroiu-SerbanescuAlexandru Obregia Clinical Psychiatric Hospital.ORCID 0000-0002-1304-6687
Paul Grof
Ryota HashimotoNational Center of Neurology and Psychiatry.ORCID 0000-0002-5941-4238
Roland Hasler
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich.ORCID 0000-0001-7135-762X
Stefan Herms
Per HoffmannInstitute of Human Genetics.
Liping HouNational Institute of Mental Health Intramural Research Program, National Institutes of Health.ORCID 0000-0003-3972-245X
YiHsiang HsuMayo Clinic.
Stéphane JamainUniv Paris Est Creteil, INSERM, IMRB.ORCID 0000-0002-4321-4100
Esther Jiménez
Jean-Pierre Kahn
Layla KassemSchool of Medicine & University Hospital Bonn.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
John KelsoeUniversity of California, San Diego.ORCID 0000-0002-3013-2333
Sarah Kittel-Schneider
Po-Hsiu KuoCollege of Public Health, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-0365-3587
Joachim Kurtz
Ichiro KusumiHokkaido University Graduate School of Medicine.ORCID 0000-0002-8747-5070
Barbara König
Gonzalo Laje
Mikael LandénGothenburg University.ORCID 0000-0002-4496-6451
Catharina LavebrattKarolinska Institutet.ORCID 0000-0003-4987-2718
Susan Leckband
Mario MajUniversity of Naples, Italy.
Mirko ManchiaDalhousie University.
Cynthia Marie-ClaireINSERM UMR-S 1144.ORCID 0000-0002-2282-134X
Lina MartinssonKarolinska Institutet.
Michael McCarthy
Susan L McElroyLindner Center of Hope / University of Cincinnati.
Vincent Millischer
Marina MitjansMax Planck Institute of Experimental Medicine, Göttingen, Germany.
Francis MondimoreNeuroscience Research Australia.
Palmiero MonteleoneUniversity of Salerno, University of Naples SUN.
Caroline NievergeltUniversity of California, San Diego.ORCID 0000-0001-5766-8923
Tomas NovakNational Institute of Mental Health, Klecany.ORCID 0000-0001-9156-9654
Markus NöthenSchool of Medicine & University Hospital Bonn.ORCID 0000-0002-8770-2464
Claire Odonovan
Norio OzakiNagoya University.ORCID 0000-0002-7360-4898
Sergi PapiolUniversity Hospital LMU.ORCID 0000-0001-9366-8728
Andrea PfennigUniversity Hospital Carl Gustav Carus, TU Dresden.
Claudia PisanuUniversity of Cagliari.ORCID 0000-0002-9151-4319
James Potash
Andreas ReifUniversity Hospital Frankfurt, Germany.ORCID 0000-0002-0992-634X
Hélène Richard-Lepouriel
Gloria Roberts
Guy RouleauMcGill University.ORCID 0000-0001-8403-1418
Janusz K RybakowskiPoznan University of Medical Sciences.ORCID 0000-0003-0577-0381
Martin SchallingKarolinska Institutet.ORCID 0000-0001-5011-2922
Peter SchofieldNeuroscience Research Australia.ORCID 0000-0003-2967-9662
Klaus Oliver SchubertUniversity of Adelaide.ORCID 0000-0003-1690-0209
Eva SchulteUniversity Hospital, LMU Munich.ORCID 0000-0003-3105-5672
Barbara Schweizer
Giovanni SeverinoUniversity of Cagliari.ORCID 0000-0002-6354-2662
Tatyana Shekhtman
Paul Shilling
Christian Simhandl
Claire Slaney
Alessio SquassinaUniversita degli Studi Di Cagliari.ORCID 0000-0001-7415-7607
Thomas StammCharité - Universitätsmedizin Berlin, Campus Charité Mitte.
Pavla Stopkova
Fabian StreitUniversity of Heidelberg.ORCID 0000-0003-1080-4339
Fasil Ayele
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.
Gustavo TureckiDouglas Institute, Department of Psychiatry, McGill University.ORCID 0000-0003-4075-2736
Julia Veeh
Eduard VietaHospital Clinic of Barcelona.ORCID 0000-0002-0548-0053
Biju ViswanathNational Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.ORCID 0000-0002-7317-1789
Stephanie WittUniversity Medical Centre Mannheim.ORCID 0000-0002-1571-1468
Peter ZandiJohns Hopkins University.
Martin AldaDalhousie University.ORCID 0000-0001-9544-3944
Michael BauerUniversity Hospital Carl Gustav Carus.ORCID 0000-0002-2666-859X
Francis McMahonNational Institute of Mental Health Intramural Research Program; National Institutes of Health.ORCID 0000-0002-9469-305X
Philip MitchellUniversity of New South Wales.ORCID 0000-0002-7954-5235
Marcella RietschelUniversity of Mannheim.ORCID 0000-0002-5236-6149
Thomas SchulzeUniversity of Munich.ORCID 0000-0001-6624-2975
Bernhard BauneUniversity of Münster.
University of Cagliari · ITWinnMed · USKarolinska Institutet · SENeuroscience Research Australia · AUThe University of Adelaide · AUDalhousie University · CAInserm · FRJohns Hopkins University · USNational Institute of Mental Health · JPPoznan University of Medical Sciences · PLUniversity Hospital Carl Gustav Carus · DEUniversity of Bonn · DEUniversity of California San Diego · USUniversity of Münster · DEUNSW Sydney · AUCentro de Investigación Biomédica en Red de Salud Mental · ESCharité - Universitätsmedizin Berlin · DEDokkyo Medical University · JPDouglas Mental Health University Institute · CAGeneva College · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi

Indexed as

bipolar disordergeneticsimmunitylithiumpolygenic scores

Identifiers

PMID37461719
PMCPMC10350128
OpenAlexW4382049886

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.