Evidence map›Paper›PMID 37462864›Full record

ArticleJournal of natural medicines2023

Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes.

Nhat Nam Hoang, Takeshi Kodama, Yu Nakashima, Kiep Minh Do, Saw Yu Yu Hnin, Yuan-E Lee, Prema, Naotaka Ikumi, Hiroyuki Morita

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nhat Nam HoangInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Takeshi KodamaInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Yu NakashimaInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Kiep Minh DoInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Saw Yu Yu HninInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
Yuan-E LeeInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan.
PremaDepartment of Chemistry, University of Yangon, Yangon, 11041, Myanmar.
Naotaka IkumiJapan Preventive Medical Laboratory Company, Ltd., 3-6-36 Toyoda, Suruga-ku, Shizuoka, 422-8027, Japan.
Hiroyuki MoritaInstitute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan. hmorita@inm.u-toyama.ac.jp.ORCID http://orcid.org/0000-0001-9963-0587
University of Toyama · JPShizuoka Medical Center · JPUniversity of Yangon · MM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arginases are bimanganese enzymes involved in many human illnesses, and thus are targets for disease treatments. The screening of traditional medicinal plants demonstrated that an ethanol extract of Curcuma comosa rhizomes showed significant human arginase I and II inhibitory activity, and further fractionation led to the isolation of three known guaiane sesquiterpenoids, alismoxide (1), 7α,10α-epoxyguaiane-4α,11-diol (2) and guaidiol (3). Tests of their inhibitory activities on human arginases I and II revealed that 1 exhibited selective and potent competitive inhibition for human arginase I (IC

Indexed as

CurcumaSesquiterpenesArginaseHumansMolecular StructureRhizomeSesquiterpenes, GuaianeArginaseguaianeSesquiterpenesSesquiterpenes, GuaianeArginase inhibitory activityCurcuma comosaGuaiane sesquiterpenoidsSesquiterpenoids

Identifiers

PMID37462864
OpenAlexW4384626186

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.