Evidence map›Paper›PMID 37463497›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.

Minzhe Guo, Kathryn A Wikenheiser-Brokamp, Joseph A Kitzmiller, Cheng Jiang, Guolun Wang, Allen Wang, Sebastian Preissl, Xiaomeng Hou, Justin Buchanan, Justyna A Karolak and 10 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. The transcriptional landscape of developing human trisomy 21 lungs.American journal of respiratory cell and molecular biology · 2026
    Article
  8. Article
  9. Endothelial Heterogeneity in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  10. Single-Cell Multiome Impact of Prenatal Heavy Metal Exposure on Early Airway Development.American journal of respiratory cell and molecular biology · 2026
    Article
  11. Article
  12. Article
  13. Basement membranes in lung development, disease, and repair.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. A Developmental Step Along the 'Omics Journey.American journal of respiratory cell and molecular biology · 2025
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 4 countries.

Minzhe GuoThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.ORCID 0000-0002-5502-9172
Kathryn A Wikenheiser-BrokampThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Joseph A KitzmillerThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Cheng JiangThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Guolun WangThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Allen WangCenter for Epigenomics & Department of Cellular & Molecular Medicine.
Sebastian PreisslCenter for Epigenomics & Department of Cellular & Molecular Medicine.
Xiaomeng HouCenter for Epigenomics & Department of Cellular & Molecular Medicine.
Justin BuchananCenter for Epigenomics & Department of Cellular & Molecular Medicine.
Justyna A KarolakDepartment of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-2340-4513
Yifei MiaoThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
David B FrankPenn-CHOP Lung Biology Institute and.ORCID 0000-0002-3064-2069
William J ZachariasThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.ORCID 0000-0002-2643-0610
Xin SunDepartment of Pediatrics, and.
Yan XuThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.ORCID 0000-0003-2025-027X
Mingxia GuThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Pawel StankiewiczDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas; and.
Vladimir V KalinichenkoThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Jennifer A WambachEdward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri.ORCID 0000-0003-1668-5174
Jeffrey A WhitsettThe Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology.
Perinatal Institute · GBEpigenomics (Germany) · DECincinnati Children's Hospital Medical Center · USBaylor College of Medicine · USChildren's Hospital of Philadelphia · USPoznan University of Medical Sciences · PLSt. Louis Children's Hospital · USUniversity of California San Diego · USUniversity of Freiburg · DE

Funding

Pilot and Feasibility ProgramP30DK117467 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin · 2018 to 2026
$11.4M
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Transcriptional Regulation of Endothelial Cells after Neonatal Lung InjuryR01HL141174 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2018 to 2026
$4.7M
LungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5M
Decoding the Cellular Niches Critical for Lung Maturation and PathogenesisU01HL148867 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUN, XIN · 2019 to 2023
$4.4M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Development of novel therapeutic approaches for treatment of Alveolar Capillary DysplasiaR01HL152973 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2021 to 2026
$3.6M
Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)R01HL153045 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN, YU, JANE · 2020 to 2023
$3.1M
Prdm3/16 Regulate Chromatin Accessibility to Determine Alveolar MaturationR01HL164414 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A · 2022 to 2025
$2.8M
Molecular Mechanisms Regulated by FOXM1 in Chronic Lung RemodelingR01HL149631 · NHLBI · UNIVERSITY OF ARIZONA · PI KALINICHENKO, VLADIMIR · 2020 to 2022
$2.2M
Elucidating the FOXF1 gene regulatory network in human alveologenesisR01HL166283 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mingxia Gu · 2023 to 2026
$1.9M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NHLBI NIH HHS R01 HL141174NHLBI NIH HHS R01 HL149631NHLBI NIH HHS R01 HL152973NHLBI NIH HHS R01 HL153045NHLBI NIH HHS R01HL153045NHLBI NIH HHS R01 HL164414NHLBI NIH HHS R01HL164414NHLBI NIH HHS R01 HL166283NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01HL122642NHLBI NIH HHS U01 HL134745NHLBI NIH HHS U01HL134745NHLBI NIH HHS U01 HL148856NHLBI NIH HHS U01HL148856NHLBI NIH HHS U01 HL148867NIDDK NIH HHS P30 DK117467NIDDK NIH HHS P30DK117467NIH HHS S10 OD026929
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Persistent Fetal Circulation SyndromeEndothelial CellsForkhead Transcription FactorsGene Regulatory NetworksHumansInfant, NewbornLungMultiomicsPulmonary AlveoliRNAVascular Endothelial Growth Factor AForkhead Transcription FactorsRNAVascular Endothelial Growth Factor Aalveolar capillary dysplasiaFOXF1pulmonary microvasculature

Identifiers

PMID37463497
PMCPMC10515568
OpenAlexW4384664339

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.